basic FUNCTION
| involved in cell cycle regulation |
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required for patterning in the eye and mitotic divisions in the ovary |
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involved in repressing a Bam-independent differentiation pathway |
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potential direct catalytic role in no-go mRNA decay |
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having inter-domain structural plasticity, suggesting that large conformational changes are essential for its functions |
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involved in the regulation of cell proliferation and stem cell self-renewal |
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binding to cytoskeleton-associated proteins may facilitate PELO to detect and degrade aberrant mRNAs, at which the ribosome is stalled during translation |
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protein complex of Pelota and HBS1L translational GTPase recognizes the stalled ribosome containing the defective mRNA |
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PELO plays an important role in the establishment of pluripotency and differentiation of ESCs into extraembryonic endoderm (ExEn) lineage through activation of BMP signaling |
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PELO is required for mammalian epidermal homeostasis |
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likely an essential role for the RNA surveillance complex PELO-HBS1L in spermatogenesis, a function that could be conserved in mammals |