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FLASH GENE
Symbol PELO contributors: mct/npt - updated : 20-03-2024
HGNC name pelota homolog (Drosophila)
HGNC id 8829
Location 5q11.2      Physical location : 52.083.773 - 52.098.449
Synonym name
  • protein Dom34 homolog
  • Synonym symbol(s) CGI-17, PRO1770, Dom34
    DNA
    TYPE functioning gene
    SPECIAL FEATURE gene in gene
    text embedded within ITGA1 intron 1
    STRUCTURE 14.68 kb     3 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    regulatory sequence Promoter
    Binding site   transcription factor
    text structure two Sp1 binding elements
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    - - 2000 - - testis 2000 11060452
    3 - 2941 - 385 ubiquitous 2000 11060452
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Endocrineadrenal gland   highly
    Lymphoid/Immunespleen   highly
    Reproductivefemale systemuterus  highly
     male systemtestis   
    Urinarykidney   highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a nuclear localization signal (NLS)
  • HOMOLOGY
    interspecies homolog to Drosophila pelota
    homolog to S. cerevisiae Dom34
    Homologene
    FAMILY
  • eukaryotic release factor 1 family
  • Pelota subfamily
  • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic,ribosome
    intracellular,cytoplasm,cytoskeleton
    intracellular,nucleus
    text
  • localized at the actin cytoskeleton
  • basic FUNCTION
  • involved in cell cycle regulation
  • required for patterning in the eye and mitotic divisions in the ovary
  • involved in repressing a Bam-independent differentiation pathway
  • potential direct catalytic role in no-go mRNA decay
  • having inter-domain structural plasticity, suggesting that large conformational changes are essential for its functions
  • involved in the regulation of cell proliferation and stem cell self-renewal
  • binding to cytoskeleton-associated proteins may facilitate PELO to detect and degrade aberrant mRNAs, at which the ribosome is stalled during translation
  • protein complex of Pelota and HBS1L translational GTPase recognizes the stalled ribosome containing the defective mRNA
  • PELO plays an important role in the establishment of pluripotency and differentiation of ESCs into extraembryonic endoderm (ExEn) lineage through activation of BMP signaling
  • PELO is required for mammalian epidermal homeostasis
  • likely an essential role for the RNA surveillance complex PELO-HBS1L in spermatogenesis, a function that could be conserved in mammals
  • CELLULAR PROCESS cell cycle,division,meiosis
    cell cycle, division, mitosis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • part of the integrin collagen receptor locus ITGA1-PELO-ITGA2
  • Pelota/HBS1L induced dissociation of elongation complexes and release of peptidyl-tRNA, but only in the presence of ABCE1
  • ABCE1/Pelota/HBS1L also dissociated vacant 80S ribosomes, which stimulated 48S complex formation, suggesting that Pelota/HBS1L have an additional role outside of stable secondary structures (NGD)
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacts with HAX1, EIF3G and SRPX proteins and that this interaction occurs at the cytoskeleton
  • binding partner of the ribosome recycling protein PELO
  • pelota protein negatively regulates the activities of bone morphogenetic protein and phosphoinositide 3-kinase (PI3K)/protein kinase B (AKT) signaling pathways in the epidermis
  • induction of the ribosome rescue factors PELO and HBS1L is required to support protein synthesis when ABCE1 levels fall and for hemoglobin production during blood cell development
  • HBS1L genetically interacts with PELO during spermatid individualization
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancerreproductiveprostate
    potential therapeutic strategy for advanced Prostate carcinoma therapy by co-targeting PLK1 and PELO
    ANIMAL & CELL MODELS
  • Pelo-deficient mice die early during gastrulation due to defects in cell proliferation and/or differentiation