Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol APMAP contributors: mct - updated : 30-05-2023
HGNC name adipocyte plasma membrane-associated protein
HGNC id 13238
Location 20p11.21      Physical location : -
Synonym name chromosome 20 open reading frame 3
Synonym symbol(s) BSCV, C20orf3, UNQ1869/PRO4305, DD16
DNA
TYPE functioning gene
STRUCTURE 29.85 kb     9 Exon(s)
motif repetitive sequence
MAPPING cloned Y linked N status confirmed
regionally located downstream and tightly linked to CST7
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
9 - 2251 46 416 - 2008 18513186
EXPRESSION
Rna function mRNAs are present in several tissues, but among the tissues tested, a remarkably higher level of expression was found in white adipose tissue
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularvesselcapillary    Homo sapiens
Digestiveliver   highly Homo sapiens
Endocrinethyroid   predominantly
Nervousbrain     Homo sapiens
 nerve   highly
Reproductivefemale systemplacenta  highly Homo sapiens
Urinarykidneynephronrenal capsuleglomerulushighly Homo sapiens
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / hematopoieticbone marrow  moderately
Connectivebone  moderately
cells
SystemCellPubmedSpeciesStageRna symbol
Cardiovascularendothelial cell Homo sapiens
cell lineage
cell lines
fluid/secretion highly in blood
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a single N-glycosylation site and an N-terminal hydrophobic stretch of 19 AAs forming a transmembrane segment, indicating that it is a glycosylated membrane-bound protein
  • extracellular C-terminal domain of APMAP is required for the function of APMAP in adipocyte differentiation
  • conjugated GlycoP
    HOMOLOGY
    Homologene
    FAMILY
  • strictosidine synthase family
  • lactonohydrolase super family
  • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    text
  • single-pass type II membrane protein
  • translocates from the endoplasmatic reticulum to the plasma membrane during adipocyte differentiation
  • basic FUNCTION
  • may play a role in adipocyte differentiation
  • may function as a novel protein involved in the cross-talk of mature adipocytes with the environment
  • having analogies with PON (paraoxonase) family members, and can represent a new member of this important protein family present at the cellular level
  • is a novel regulator of extracellular matrix components
  • APMAP functions likely as a modulator promoting HCMV infection in multiple cell types and is an important player in the complex HCMV infection mechanism
  • involved in lipid transport and can induce epithelial-mesenchymal transition of prostate cancer and the liver metastasis of colorectal cancer
  • CELLULAR PROCESS cell life, differentiation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with PPARG (through a functional PPARG binding site)
  • APMAP interacts physically with gamma-secretase and its substrate APP
  • APMAP is a negative regulator of Abeta production through its interaction with APP and gamma-secretase
  • APMAP interacts with the extracellular collagen cross-linking matrix proteins lysyl oxidase-like 1 and 3
  • HSPA1A and M6PR negatively regulated APP processing and Abeta production
  • cell & other
    REGULATION
    induced by strongly induced by the PPARG ligand rosiglitazone in adipocytes in adipose tissue
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in cervical cancer tissues, and patients with high expression had poor prognosis
    constitutional       loss of function
    leads to beneficial visceral adipose tissue expansion
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • APMAP is a potential prognostic marker as well as a therapeutic target of cervical cancer
  • Therapy target
    SystemTypeDisorderPubmed
    cancerreproductiveuterus
    is a therapeutic target of cervical cancer
    ANIMAL & CELL MODELS