basic FUNCTION
| involved in regulation of transcription, DNA-dependent, histogenesis and organogenesis, neurogenesis |
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may function as a transcriptional repressor |
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may be involved in the regulation of ventricular septation in humans |
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suppresses atrial identity in the left ventricular compact myocardium, facilitates myocardial proliferation by suppressing TBX5, and thereby promotes proper ventricular myocardial maturation |
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with HEY1, are the downstream mediators of the prosensory function of Notch in early cochlear development |
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functions in parallel with HES1 and HES5 in patterning the organ of Corti, and interacts genetically with HES1 for early embryonic development and survival |
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its expression levels influence hypertrophy and the progression to heart failure in response to pressure overload through modulation of apoptosis and GATA4 activity |
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potentially regulating the later steps of coronary vascular development in both a myocardial-dependent, non-cell autonomous fashion and likely a vascular cell-specific effect as well |
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HESR family (HEY1, HEY2, HEYL)is involved in dopamine transporter expression (SLC6A3) via the VNTR domain |
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HEY1 and HEY2 selectively repress androgen receptor (AR) signaling in mammalian cell lines |
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play an important role in regulation of vascular smooth muscle phenotype and gene expression |
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involved in the transcriptional regulation of MMP10 |
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transcriptional regulator of cardiac electrical function involved in the pathogenesis of Brugada syndrome |
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critical scaffolding function for HEY1, HEY2 that is required for forming an active retrotranslocation complex containing SYVN1, SEL1L, and DERL2 |
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critical role for HEY1 and HEY2 in prosensory cell maintenance and identifies Hedgehog signaling as a novel upstream regulator of their prosensory function in the mammalian cochlea |
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important role of HEY1 and HEY2 in endothelial cells during early vascular development |