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FLASH GENE
Symbol WDR4 contributors: mct/npt - updated : 25-09-2019
HGNC name WD repeat domain 4
HGNC id 12756
Corresponding disease
GAMOS6 Galloway-Mowat syndrome 6
MIGSB microcephaly, growth deficiency, seizures, and brain malformations
Location 21q22.3      Physical location : 44.263.205 - 44.299.678
Synonym name
  • WD repeat-containing protein 4
  • tRNA (guanine-N(7)-)-methyltransferase subunit WDR4
  • TRM82 tRNA methyltransferase 82 homolog
  • protein Wuho homolog
  • Synonym symbol(s) TRM82, GAMOS6, MIGSB, TRMT82, hWH, WUHO
    DNA
    TYPE functioning gene
    STRUCTURE 48.62 kb     12 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    motif repetitive sequence   ALU   long interspersed repetitive elements
    MAPPING cloned Y linked N status provisional
    Map cen - D21S398 - MX2 - D21S1260 - MX1 - D21S212 - [D21S1455 - D21S399 - D21S1225 - D21S19 - D21S49 - D21S113 - D21S1456 - CBS - D21S1457 ] - D21S141 - qter
    Authors Michaud (00)
    Text [DFNB10 ]
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    12 - 1524 - 412 - 2015 26416026
    11 - 2155 - 412 - 2015 26416026
    11 - 2016 - 266 - 2015 26416026
    11 - 2116 - 266 - 2015 26416026
    11 - 2165 - 411 - 2015 26416026
    11 - 2223 - 266 - 2015 26416026
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    blood / hematopoieticspleen   lowly
    Digestiveintestinesmall intestine   
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / Hematopoieticbone marrow   
    Connectivebone   
    Lymphoid    
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period fetal, pregnancy
    Text tissues, brain, kidney, heart, placenta
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • two WD repeat
  • S-adenosylmethionine binding domain
  • HOMOLOGY
    interspecies ortholog to drosophila wuho
    Homologene
    FAMILY
  • WD repeat TRM82 family
  • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus,nucleoplasm
    basic FUNCTION
  • is required for m7G-methyltransferase activity (Alexandrov 2002)
  • localization of WDR4 at the site of nascent DNA synthesis along with other replication proteins, including FEN1 and PCNA
  • is an oncoprotein that negatively regulates PML via ubiquitination to promote lung cancer progression by fostering an immunosuppressive and prometastatic tumor microenvironment
  • CELLULAR PROCESS nucleotide, genomic integrity
    PHYSIOLOGICAL PROCESS development
    PATHWAY
    metabolism
    signaling
    a component
  • form a complex with WDR4 (Alexandrov 2002)
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • WDR4-FEN1 interaction may have a critical role in the growth and development, and in the maintenance of genome stability
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) GAMOS6 , MIGSB
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS