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FLASH GENE
Symbol CHST5 contributors: mct/npt - updated : 07/11/2008
HGNC name carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 5
HGNC id 1973
Location 16q23.1      Physical location : 75.562.429 - 75.569.068
Synonym name
  • N-acetylglucosamine 6-O sulfotransferase intestinal
  • intestinal GlcNAc-6- sulfotransferase
  • galactose/N- acetylglucosamine/N-acetylglucosamine
  • Synonym symbol(s) IGLCNAC6ST, I-GLCNAC-6-ST, FLJ22167, GST4-alpha, MGC74625, CGn6ST
    EC.number 2.8.2.-
    DNA
    TYPE like-sequence
    STRUCTURE 6.64 kb     3 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    regulatory sequence
    MAPPING cloned Y linked N status provisional
    regionally located 30kb upstream CHST6
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    - - - 2800 - 390 - -
    3 - 3265 - 411 - Kitayama (2007)
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestinelarge intestinecolon  
     intestinesmall intestine   
    Hearing/Equilibriumear   highly
    Nervousbrain    
    Respiratoryrespiratory tracttrachea  highly
    Urinarykidney    
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period fetal
    Text liver
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • N terminal cytoplasmic tail of 9AA
  • a single transmembrane domain
  • extracellular domain
  • three potential N glycosylation sites
  • conjugated GlycoP
    HOMOLOGY
    interspecies homolog to murine Chst5
    homolog to Drosophila CG1332
    homolog to C.elegans T01H10.8
    intraspecies paralog to LSST,CHST1
    Homologene
    FAMILY
  • sulfotransferase family
  • Gal/GlcNAc/GalNAc subfamily
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,Golgi
    basic FUNCTION
  • 6.0 sulfotransferase activity
  • involved in sulfation of glycoproteins and proteoglycans
  • involved in matrix morphogenesis in cornea
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism carbohydrate
    signaling
    sulfation of glycoprotein and proteoglycans
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS