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FLASH GENE
Symbol PDC contributors: mct - updated : 10-12-2014
HGNC name phosducin
HGNC id 8759
Location 1q25.2      Physical location : 186.412.718 - 186.430.239
Synonym name
  • 33kDA phototransducing protein
  • G beta gamma binding protein
  • phosducin-like orphan protein
  • Synonym symbol(s) MEKA, PHD, PhLOP, PhLP
    DNA
    TYPE functioning gene
    STRUCTURE 17.00 kb     3 Exon(s)
    Genomic sequence alignment details
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked   status confirmed
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    - splicing 1258 28.2 246 - Nishigushi
    - splicing 1221 - 194 - Nishigushi
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Endocrinepineal    
    Visualeyeretina  predominantly Homo sapiens
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelialsensoryvisual  
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Visualcone photoreceptor Homo sapiens
    Visualrod photoreceptor Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a phosducin domain
  • HOMOLOGY
    interspecies ortholog to murine Pdc (86 pc)
    Homologene
    FAMILY phosducin family
    CATEGORY signaling , receptor membrane G
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • (transducin) inhibitor protein, participating in the regulation of visual phototransduction or in the integration of photoreceptor metabolism
  • previously unrecognized target of SUMO modification and SUMOylation controls phosducin stability in cells as well as its functional properties
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction , sensory transduction/vision
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    Other regulated at the posttranslational level by modification with the small ubiquitin-related modifier, SUMO
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS