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FLASH GENE

Symbol

SLAMF1

contributors: mct - updated : 16-02-2017

HGNC name	signaling lymphocytic activation molecule family member 1
HGNC id	10903

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

EXPRESSION

Type	restricted

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Lymphoid/Immune lymph node           thymus         Reproductive female system breast mammary gland       female system placenta

cells

System Cell Pubmed Species Stage Rna symbol Blood/Hematopoietic monocyte Blood/Hematopoietic thymocyte Lymphoid/Immune B cell Lymphoid/Immune dendritic cell Lymphoid/Immune T cell

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	one immunoglobulin-like C2-type domain
	one immunoglobulin-like V-type domain

conjugated

GlycoP

HOMOLOGY

Homologene

FAMILY	CD2 immunoglobulin superfamily
	SLAM subfamily

CATEGORY

immunity/defense , regulatory , receptor membrane G

SUBCELLULAR LOCALIZATION	extracellular
	plasma membrane

basic FUNCTION	transmembrane receptor activity
	mediates intracellular protein tyrosine phosphorylation signals dependent on the binding affinity to SAP
	involved in T cell stimulation and cytokine production
	may play an important role in the regulation of immune responses to pathogens
	mediate important regulatory signals in immune cells, as a result of their exquisite ability to associate with members of the SLAM-associated protein (SAP) family of adaptors (Veillette 2007)
	role in the regulation of adaptive and innate immune responses (Calpe 2008)
	prominent role for SLAM receptor ligation in IL4 production by GC (Germinal center) CD4 T cells but not in T(FH) cell and GC T(FH) cell differentiation (Yusuf 2010)
	with its receptor modulate T cell functions (Detre 2010)
	connects the gram-negative bacterial phagosome to ubiquitous cellular machinery responsible for the control of bacterial killing
	SLAMF1, CD48, CD84, CD244, LY9, SLAMF6, SLAMF7 play an essential and non-redundant role in the control of humoral immune responses
	SLAMF1 recruits a subset of PIK3C3-associated proteins, which is involved in membrane fusion and CYBB regulation
	natural killer T (NKT) cells and innate CD8(+) T cell development can be regulated in a SAP-dependent and -independent fashion by SLAMF receptors, in which SLAMF1, SLAMF6, and SLAMF8 affect development of NKT cells, and CD84, SLAMF7, and SLAMF8 affect the development of innate CD8(+) T cells
	is a member of the CD2 superfamily, a costimulatory lymphocyte receptor, a receptor for measles virus, and a microbial sensor on macrophages
	cell surface receptor SLAMF1 (CD150) is requisite for optimal NADPH-oxidase (Nox2) dependent reactive oxygen species (ROS) production by phagocytes in response to Gram- bacteria
	SLAMF1 and SLAMF8 govern ROS-dependent innate immune responses of myeloid cells, thus modulating migration of these cells during inflammation in an opposing manner
	SLAMF1, CD84, and SLAMF6 are important negative regulators of humoral immune response, consistent with the notion that SLAM family receptors have dual functions in immune responses
	SLAMF1 and CD180 are involved in regulation of transcription factors expression in chronic lymphocytic leukemia cells (

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

immunity/defense

text	immuno stimulatory function

PATHWAY

metabolism

signaling

SLAM-SH2D1A signaling pathway

a component

INTERACTION

DNA

RNA

small molecule

protein	interacts with SH2 domain protein 1A (SH2D1A) and PTPN11
	SLAMF1 interacts with the class III PIK3C3 in a complex with BECN1 and UVRAG

cell & other

receptor for the measles virus, via its V domain

REGULATION

repressed by

stimulated by antigen (memory cell)

Other	expression upregulated by IL-1B
	phosphorylated by FYN
	down-regulated on lymphocytes by measles virus

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral       loss of function in Chronic lymphocytic leukemia (CLL) modulates genetic pathways that regulate chemotaxis and autophagy and that potentially affect drug responses constitutional     --over   significantly increased expression of SLAMF1 by CD3+CD4+ helper T cells and CD19+ B cells in patients with SLE and active disease

Susceptibility

Variant & Polymorphism

Candidate gene
Marker	new diagnostic marker in CNS tumors
Therapy target
	System Type Disorder Pubmed cancer brain   potential target for novel therapeutic approaches in CNS tumors

ANIMAL & CELL MODELS