SUBCELLULAR LOCALIZATION
| extracellular
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| intracellular
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| intracellular,cytoplasm,organelle,membrane
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| intracellular,cytoplasm,organelle,endoplasmic reticulum
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| intracellular,cytoplasm,cytosolic
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text
| extracellular matrice remodeling |
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in the skin, SPINK5, KLK7, and KLK5 were all found in the lamellar granule (LG) system, but were separately localized |
basic FUNCTION
| involved in skin and hair morphogenesis and anti-inflammatory and/or antimicrobial protection of mucous epithelia |
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key regulator of the proteolytic events occurring during epidermal barrier formation and hair development |
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multidomain serine protease inhibitor which plays a central role in skin permeability barrier and allergy |
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plays a crucial role in deciding the timing of desquamation of the skin, and its gene expression is limited at the very surface of the stratum granulosum (SG) |
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GATA3 is important for inhibition of proliferation and induction of differentiation of keratinocytes, but its effect on SPINK5 expression was indirect and GATA3 alone was insufficient for final differentiation of keratinocytes where full SPINK5 expression was observed |
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essential molecule for the epidermal skin barrier |