Selected-GenAtlas references	SOURCE	GeneCards	NCBI Gene	Swiss-Prot	Ensembl
	HGNC	UniGene	Nucleotide	OMIM	UCSC

Home Page

FLASH GENE

Symbol

BACE2

contributors: mct - updated : 07-12-2016

HGNC name	beta-site APP-cleaving enzyme 2
HGNC id	934

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional     --over   in Down syndrome constitutional     --over   in patients with preclinical to late-stage AD, and also elevated in frontotemporal dementia

Susceptibility

to Alzheimer disease (AD)

Variant & Polymorphism SNP	haplotype (H5) was found to associate with AD, but haplotype (H7) showed a weaker association with protection against AD

Candidate gene	particulary strong therapeutic candidate for the treatment or prevention of AD
Marker
Therapy target
	System Type Disorder Pubmed neurology neurodegenerative alzheimer therapeutic interventions that potentiate BACE2 may prevent AD pathogenesis

ANIMAL & CELL MODELS