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FLASH GENE
Symbol CPA2 contributors: mct - updated : 02-05-2014
HGNC name carboxypeptidase A2 (pancreatic)
HGNC id 2297
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • short leader sequence and a 94 AA long activation peptide
  • a catalytic moiety with a zinc binding domain
    • conjugated MetalloP
    mono polymer monomer
    isoforms Precursor
    HOMOLOGY
    Homologene
    FAMILY zinc carboxypeptidase family
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION extracellular
    basic FUNCTION
  • cleaving substrates with C terminal hydrophobic residues
  • CPA1, CPA2 might play a role in the renin-angiotensin system in addition to their functions as digestive enzymes
  • CPA1 and CPA2 act on aromatic and aliphatic amino acid residues that are exposed by the action of chymotrypsins and elastases
    • CELLULAR PROCESS protein, degradation
    PHYSIOLOGICAL PROCESS digestion
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
    zinc Zn2+
    protein
  • CTRC is a physiological co-activator of proCPA1 and proCPA2 and is a key regulator of digestive zymogen activation
    • cell & other
    REGULATION
    activated by proteolytic cleavage at the C-terminal end of the propeptide by trypsin
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS