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FLASH GENE
Symbol CPA2 contributors: mct - updated : 02-05-2014
HGNC name carboxypeptidase A2 (pancreatic)
HGNC id 2297
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Endocrinepancreas   highly Homo sapiens
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Epithelialsecretoryglandularendocrine 
Epithelialsecretoryglandularexocrine 
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • short leader sequence and a 94 AA long activation peptide
  • a catalytic moiety with a zinc binding domain
    • conjugated MetalloP
    mono polymer monomer
    isoforms Precursor
    HOMOLOGY
    Homologene
    FAMILY zinc carboxypeptidase family
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION extracellular
    basic FUNCTION
  • cleaving substrates with C terminal hydrophobic residues
  • CPA1, CPA2 might play a role in the renin-angiotensin system in addition to their functions as digestive enzymes
  • CPA1 and CPA2 act on aromatic and aliphatic amino acid residues that are exposed by the action of chymotrypsins and elastases
    • CELLULAR PROCESS protein, degradation
    PHYSIOLOGICAL PROCESS digestion
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
    zinc Zn2+
    protein
  • CTRC is a physiological co-activator of proCPA1 and proCPA2 and is a key regulator of digestive zymogen activation
    • cell & other
    REGULATION
    activated by proteolytic cleavage at the C-terminal end of the propeptide by trypsin
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS