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FLASH GENE

Symbol

CPA2

contributors: mct - updated : 02-05-2014

HGNC name	carboxypeptidase A2 (pancreatic)
HGNC id	2297

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
SPECIAL FEATURE	component of a cluster
text	member of a cluster of carboxypeptidase on chromosome 7 with CPA1, CPA4 and CPA5
STRUCTURE	22.94 kb     11 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_001869 11 - 1342 NP_001860 - 419 - 2002 11836249

EXPRESSION

Type

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Endocrine pancreas       highly Homo sapiens

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Epithelial secretory glandular endocrine   Epithelial secretory glandular exocrine

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	short leader sequence and a 94 AA long activation peptide
	a catalytic moiety with a zinc binding domain

conjugated

MetalloP

mono polymer

monomer

isoforms

Precursor

HOMOLOGY

Homologene

FAMILY

zinc carboxypeptidase family

CATEGORY

enzyme

SUBCELLULAR LOCALIZATION

extracellular

basic FUNCTION	cleaving substrates with C terminal hydrophobic residues
	CPA1, CPA2 might play a role in the renin-angiotensin system in addition to their functions as digestive enzymes
	CPA1 and CPA2 act on aromatic and aliphatic amino acid residues that are exposed by the action of chymotrypsins and elastases

CELLULAR PROCESS

protein, degradation

PHYSIOLOGICAL PROCESS

digestion

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule	metal binding,
	zinc Zn2+

protein

CTRC is a physiological co-activator of proCPA1 and proCPA2 and is a key regulator of digestive zymogen activation

cell & other

REGULATION

activated by

proteolytic cleavage at the C-terminal end of the propeptide by trypsin

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS