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FLASH GENE

Symbol

CCHCR1

contributors: - updated : 16-02-2006

HGNC name	coiled-coil alpha-helical rod protein 1
HGNC id	13930

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

alpha helical coils

HOMOLOGY

interspecies	homolog to Drosophila CG6197
	homolog to C.elegans C50F2.3
	ortholog to chimpazee hcr
	ortholog to murine Cchcr1

Homologene

FAMILY

CATEGORY

regulatory

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm
	intracellular,nucleus

basic FUNCTION

may be a regulator of keratinocyte proliferation or differentiation

CELLULAR PROCESS	cell life, differentiation

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

cell & other

REGULATION

inhibited by

interferon-gamma in keratinocytes

ASSOCIATED DISORDERS

corresponding disease(s)

Susceptibility

psoriasis (PSORS1)

Variant & Polymorphism SNP	associated with PSORS1

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS