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FLASH GENE

Symbol

EPB41L3

contributors: mct - updated : 09-09-2011

HGNC name	erythrocyte membrane protein band 4.1-like 3
HGNC id	3380

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --other   differentially expressed in adenocarcinoma of the lung and in meningioma atypical or anaplastic (sporadic) tumoral     --low   in meningioma tumoral   LOH     in breast cancer in progression tumoral         extensively methylated in ovarian cancer cell lines and primary ovarian tumors compared with normal tissues

Susceptibility

to meningioma

Variant & Polymorphism other	low mutational frequency in the neoplastic transformation of meningiomas, and other inactivating mechanisms, such as epigenetic changes, may participate in EPB41L3 silencing

Candidate gene
Marker
Therapy target
	System Type Disorder Pubmed cancer reproductive prostate target for prostate cancer therapy cancer reproductive ovary reexpression of EPB41L3 induces extensive apoptotic cell death in ovarian cancers

ANIMAL & CELL MODELS