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FLASH GENE
Symbol BARHL2 contributors: mct/npt - updated : 28-08-2013
HGNC name BarH-like homeobox 2
HGNC id 954
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • helix turn helix protein (homeobox)
    • HOMOLOGY
    interspecies homolog to Drosophila BarH
    Homologene
    FAMILY
  • BAR homeobox family
    • CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • may play a crucial role in cell fate determination of neural structures
  • may function to specify the identity of glycinergic amacrine cells from competent progenitors during retinogenesis
  • appears to have numerous roles in retinal development, including regulating neuronal subtype specification, differentiation, and survival
  • BARHL1, BARHL2 share a conserved function as cell type-specific regulators of Caspase3 activities
  • critical postmitotic regulator of dI1 (dorsal interneurons 1) subtype diversification, as well as its intermediate position in the dI1 genetic hierarchy
  • central function of BARHL2 in the postmitotic divergence of dI1 neurons into distinct dI1i and dI1c subtypes, and establish its intermediate position in the dI1 genetic hierarchy
    • CELLULAR PROCESS nucleotide, transcription
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • ATOH7 itself influences the subtypes of BARHL2-dependent amacrine cells
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • Barhl2-nulls mice survive up to the third postnatal week and exhibit ataxia that is characterized by unstable gait, abrupt limb movements, and bunching of the trunk during tail suspension