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FLASH GENE
Symbol BARHL2 contributors: mct/npt - updated : 28-08-2013
HGNC name BarH-like homeobox 2
HGNC id 954
Location 1p22.2      Physical location : 91.177.579 - 91.182.794
Synonym name BarH-like 2 (Drosophila)
DNA
TYPE functioning gene
STRUCTURE 5.22 kb     3 Exon(s)
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
3 - 1496 41 387 - 2000 10814725
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveliver   highly
Lymphoid/Immunethymus   highly
Nervousbraindiencephalon  highly Mus musculusFetal
 spinal cord   highly Mus musculusFetal
Visualeyeretina    Homo sapiens
cells
SystemCellPubmedSpeciesStageRna symbol
Nervousneuron Mus musculusFetal
Visualamacrine cell Homo sapiens
Visualganglion cell Homo sapiens
Visualhorizontal association cell Homo sapiens
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • helix turn helix protein (homeobox)
  • HOMOLOGY
    interspecies homolog to Drosophila BarH
    Homologene
    FAMILY
  • BAR homeobox family
  • CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • may play a crucial role in cell fate determination of neural structures
  • may function to specify the identity of glycinergic amacrine cells from competent progenitors during retinogenesis
  • appears to have numerous roles in retinal development, including regulating neuronal subtype specification, differentiation, and survival
  • BARHL1, BARHL2 share a conserved function as cell type-specific regulators of Caspase3 activities
  • critical postmitotic regulator of dI1 (dorsal interneurons 1) subtype diversification, as well as its intermediate position in the dI1 genetic hierarchy
  • central function of BARHL2 in the postmitotic divergence of dI1 neurons into distinct dI1i and dI1c subtypes, and establish its intermediate position in the dI1 genetic hierarchy
  • CELLULAR PROCESS nucleotide, transcription
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • ATOH7 itself influences the subtypes of BARHL2-dependent amacrine cells
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • Barhl2-nulls mice survive up to the third postnatal week and exhibit ataxia that is characterized by unstable gait, abrupt limb movements, and bunching of the trunk during tail suspension