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FLASH GENE
Symbol TAF1C contributors: mct/npt - updated : 17-06-2020
HGNC name TATA box binding protein (TBP)-associated factor, RNA polymerase I, C, 110kDa
HGNC id 11534
Location 16q24.1      Physical location : 84.211.461 - 84.220.662
Synonym name
  • selectivity factor 1
  • SL1, 110kD subunit
  • TATA box-binding protein-associated factor 1C
  • Synonym symbol(s) TAFI110, FAFI95, SL1, TAFI95, TAF(I)110, MGC:39976
    DNA
    TYPE functioning gene
    STRUCTURE 9.22 kb     14 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    14 splicing 3925 - 869 - 2015 25551296
    15 splicing 3741 - 775 - 2015 25551296
    12 - 3518 - 537 - 2015 25551296
    14 - 3814 - 460 - 2015 25551296
    15 - 3847 - 843 - 2015 25551296
    11 - 3342 - 537 - 2015 25551296
    12 - 3659 - 392 - 2015 25551296
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   highly
    Nervousbrain   highly
     spinal cord   highly
    Reproductivemale systemprostate  highly
    Respiratorylung   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Nervouscentral   
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    interspecies homolog to murine Taf1c
    Homologene
    FAMILY
    CATEGORY DNA associated , transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus,nucleoplasm
    intracellular,nucleus,nucleolus
    basic FUNCTION
  • playing a role in the initiation of transcription by RNA polymerase 1
  • initiation of transcription for ribosomal RNA (rRNA) by RNA polymerase I requires TBP and TBP-associated factors (TAF1A, TAF1B and TAF1C)
  • CELLULAR PROCESS nucleotide, transcription
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • component of SL1 (complex composed of the TATA-binding protein (TBP) and three TBP-associated factors (TAFs) specific for RNA polymerase I), general transcription factor associated with POLR1, synthesis of 45S RNA precursors
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with TP53 (Tp53 binds to SL1, and this interaction is mostly mediated by direct contacts with TATA-binding protein and TAF1C)
  • TBP loading by AFF1 through TAF1A, TAF1B, TAF1C is the major rate-limiting step in MLL fusion-dependent transcription
  • SPIN1 is required for the association or assembly of selective factor 1 (TAF1C) complex, probably facilitating the initiation of rDNA transcription
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral somatic mutation      
    somatic frameshift mutations in in gastric and colorectal cancers
    constitutional     --over  
    in T2DM
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS