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FLASH GENE
Symbol TAF1B contributors: mct - updated : 24-10-2015
HGNC name TATA box binding protein (TBP)-associated factor, RNA polymerase I, B, 63kDa
HGNC id 11533
Location 2p25.1      Physical location : 9.983.570 - 10.074.543
Synonym name
  • Selectivity Factor 1
  • SL1, 63kD subunit
  • TBP-associated factor 1B
  • TATA box-binding protein-associated factor 1B
  • transcription initiation factor SL1/TIF-IB subunit B
  • Synonym symbol(s) TAFI63, SL1, TAF(I)63, RAF1B, RAFI63,
    DNA
    TYPE functioning gene
    STRUCTURE 91.00 kb     15 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    15 - 2306 - 588 - -
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveesophagus   highly
     liver   highly
    Reproductivefemale systemplacenta  highly
    Respiratoryrespiratory tractlarynx  highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • N-terminal zinc ribbon and cyclin-like fold domains
  • HOMOLOGY
    Homologene
    FAMILY
    CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm
    intracellular,nucleus,nucleoplasm
    basic FUNCTION
  • template activating factor I
  • binding to the core promoter of ribosomal RNA genes to position the polymerase properly and acting as a channel for regulatory signals
  • assembly of TBP and associated factors (TAFs), essential for preinitiation complex formation at ribosomal RNA gene promoters
  • essential for Pol I recruitment to the ribosomal RNA gene promoter, also has an essential postpolymerase recruitment role
  • GTF2B-like factor, having a key function in Pol I transcription
  • initiation of transcription for ribosomal RNA (rRNA) by RNA polymerase I requires TBP and TBP-associated factors (TAF1A, TAF1B and TAF1C)
  • CELLULAR PROCESS nucleotide, transcription
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component component of SL1 (complex composed of the TATA-binding protein (TBP) and three TBP-associated factors (TAFs) specific for RNA polymerase I), general transcription factor associated with POLR1, synthesis of 45S RNA precursors
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • tata box binding (TBP) specifically interacting with mitotic cyclin B
  • TBP loading by AFF1 through TAF1A, TAF1B, TAF1C is the major rate-limiting step in MLL fusion-dependent transcription
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS