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FLASH GENE

Symbol

TAF1B

contributors: mct - updated : 24-10-2015

HGNC name	TATA box binding protein (TBP)-associated factor, RNA polymerase I, B, 63kDa
HGNC id	11533

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	2p25.1      Physical location : 9.983.570 - 10.074.543
Synonym name	Selectivity Factor 1
	SL1, 63kD subunit
	TBP-associated factor 1B
	TATA box-binding protein-associated factor 1B
	transcription initiation factor SL1/TIF-IB subunit B
Synonym symbol(s)	TAFI63, SL1, TAF(I)63, RAF1B, RAFI63,

DNA

TYPE	functioning gene
STRUCTURE	91.00 kb     15 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_005680 15 - 2306 NP_005671 - 588 - -

EXPRESSION

Type

widely

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive esophagus       highly   liver       highly Reproductive female system placenta     highly Respiratory respiratory tract larynx     highly

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

N-terminal zinc ribbon and cyclin-like fold domains

HOMOLOGY

Homologene

FAMILY

CATEGORY

transcription factor

SUBCELLULAR LOCALIZATION	plasma membrane
	intracellular
	intracellular,cytoplasm
	intracellular,nucleus,nucleoplasm

basic FUNCTION	template activating factor I
	binding to the core promoter of ribosomal RNA genes to position the polymerase properly and acting as a channel for regulatory signals
	assembly of TBP and associated factors (TAFs), essential for preinitiation complex formation at ribosomal RNA gene promoters
	essential for Pol I recruitment to the ribosomal RNA gene promoter, also has an essential postpolymerase recruitment role
	GTF2B-like factor, having a key function in Pol I transcription
	initiation of transcription for ribosomal RNA (rRNA) by RNA polymerase I requires TBP and TBP-associated factors (TAF1A, TAF1B and TAF1C)

CELLULAR PROCESS

nucleotide, transcription

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

component of SL1 (complex composed of the TATA-binding protein (TBP) and three TBP-associated factors (TAFs) specific for RNA polymerase I), general transcription factor associated with POLR1, synthesis of 45S RNA precursors

INTERACTION

DNA

RNA

small molecule

protein	tata box binding (TBP) specifically interacting with mitotic cyclin B
	TBP loading by AFF1 through TAF1A, TAF1B, TAF1C is the major rate-limiting step in MLL fusion-dependent transcription

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS