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FLASH GENE

Symbol

DSC1

contributors: mct - updated : 08-11-2010

HGNC name	desmocollin 1
HGNC id	3035

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional     --low   with DSC1, were dramatically reduced in the upper most living layers of the epidermis in Netherton syndrome tumoral     --other   de novo expression in colorectal cancer

Susceptibility

to Alzheimer disease

Variant & Polymorphism other	polymorphism modulating AD susceptibility in a gender-specific manner

Candidate gene
Marker	autoantigen of the subcorneal pustular dermatosis type was identified as DSC1
Therapy target

ANIMAL & CELL MODELS