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Symbol MRPL3 contributors: mct - updated : 27-05-2013
HGNC name mitochondrial ribosomal protein L3
HGNC id 10379
Corresponding disease
COXPD9 combined oxidative phosphorylation deficiency 9
Location 3q22.1      Physical location : 131.181.045 - 131.221.829
Synonym name
  • 39S ribosomal protein L3, mitochondrial
    • Synonym symbol(s) MRL3, RPML3, COXPD9
    DNA
    TYPE functioning gene
    STRUCTURE 40.82 kb     10 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    10 - 1781 - 348 - -
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    interspecies homolog to murine Mrpl3
    Homologene
    FAMILY
    CATEGORY RNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria,matrix
    intracellular,cytoplasm,cytosolic,ribosome
    text mitochondrial ribosome
    basic FUNCTION
  • mitochondrial proteins biosynthesis
  • ribosomal structure and biogenesis
  • ribosomal protein exclusively found in mitochondria (
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component component of the large subunit (39S) of the mitochondrial ribosome, including two RNA molecules and, at leasr, 70 proteins among which 47 proteins for the large sununit
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) COXPD9
    Susceptibility to Tourette syndrome or chronic tic disorder
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS