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FLASH GENE
Symbol TBXA2R contributors: mct/npt - updated : 12-02-2010
HGNC name thromboxane A2 receptor
HGNC id 11608
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • seven transmembrane segments (7TM) receptor
  • conserved NPXXY motif in transmembrane domain 7 that is a key structural element in family A G protein-coupled receptors
  • ligand binding site within the C-terminal portion of the third extracellular domain
    • HOMOLOGY
    Homologene
    FAMILY
  • G-protein coupled receptor 1 family
    • CATEGORY receptor
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • receptor for thromboxane a2 (TXA2), a potent stimulator of platelet aggregation
  • play important roles in the pathogenesis of aspirin-intolerant asthma
  • has a significant prognostic value in clinical breast cancer
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interaction between TBXA2R, receptor involved in oxidative stress and PRDX4, an anti-oxidative enzyme
  • interacts with the GNAQ, thereby activating phospholipase C and increasing the intracellular calcium level
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) TBXA2R
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in aggressive breast tumours and linked with poor prognosis
    Susceptibility asthma in japanese population
    Variant & Polymorphism SNP T924C polymorphism potentially associated with bronchial asthma in a Japenese population
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS