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FLASH GENE
Symbol TBXA2R contributors: mct/npt - updated : 12-02-2010
HGNC name thromboxane A2 receptor
HGNC id 11608
EXPRESSION
Type
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Urinarykidney    
cells
SystemCellPubmedSpeciesStageRna symbol
Blood/Hematopoieticleukocyte
Endocrineislet cell (alpha,beta...)
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • seven transmembrane segments (7TM) receptor
  • conserved NPXXY motif in transmembrane domain 7 that is a key structural element in family A G protein-coupled receptors
  • ligand binding site within the C-terminal portion of the third extracellular domain
    • HOMOLOGY
    Homologene
    FAMILY
  • G-protein coupled receptor 1 family
    • CATEGORY receptor
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • receptor for thromboxane a2 (TXA2), a potent stimulator of platelet aggregation
  • play important roles in the pathogenesis of aspirin-intolerant asthma
  • has a significant prognostic value in clinical breast cancer
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interaction between TBXA2R, receptor involved in oxidative stress and PRDX4, an anti-oxidative enzyme
  • interacts with the GNAQ, thereby activating phospholipase C and increasing the intracellular calcium level
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) TBXA2R
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in aggressive breast tumours and linked with poor prognosis
    Susceptibility asthma in japanese population
    Variant & Polymorphism SNP T924C polymorphism potentially associated with bronchial asthma in a Japenese population
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS