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FLASH GENE
Symbol CETP contributors: mct - updated : 21-02-2007
HGNC name cholesteryl ester transfer protein, plasma
HGNC id 1869
Corresponding disease
CETPD cholesteryl ester transfer protein deficiency
Location 16q13      Physical location : 56.995.834 - 57.017.756
Synonym name plasma lipid transfer protein
DNA
TYPE functioning gene
STRUCTURE 21.92 kb     16 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked Y status confirmed
Physical map
MT2A 16q13 metallothionein 2A MT1L 16q13 metallothionein 1L MT1E 16q13 metallothionein 1E (functional) MT1K 16q13 metallothionein 1K MT1J 16q13 metallothionein 1J MT1A 16q13 metallothionein 1A (functional) LOC390733 16 similar to MTM MT1B 16q13 metallothionein 1B (functional) MT1F 16q13 metallothionein 1F (functional) MT1G 16q13 metallothionein 1G MT1H 16q13 metallothionein 1H MT1X 16q13 metallothionein 1X KIAA0095 16q13 metallothionein 1X SLC12A3 16q13 solute carrier family 12 (sodium/chloride transporters), member 3 HERPUD1 16q12.2-13 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 CETP 16q13 cholesteryl ester transfer protein, plasma NOD27 16q13 nucleotide-binding oligomerization domains 27 CPNE2 16q13 copine II NIP30 16q13 NEFA-interacting nuclear protein NIP30 KIAA1972 16q13 KIAA1972 protein
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
16 - 1717 53.1 493 - -
EXPRESSION
Type
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
blood / hematopoieticspleen    
Digestiveintestinesmall intestine   
 liver    
Endocrineadrenal gland    
Nervousbrain    
Urinarykidney    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Connectiveadipose   
Connectivecartilage   
Epithelialsecretoryglandularendocrine 
Lymphoid    
cell lineage in and throughout differentiation of preadipocyte
cell lines
fluid/secretion plasma
at STAGE
PROTEIN
PHYSICAL PROPERTIES Hydrophobic
STRUCTURE
motifs/domains
  • a signal peptide
  • a N terminal half with a LPS binding site
  • a conserved C terminal, required for anchoring lipoprotein particles
  • conjugated GlycoP
    HOMOLOGY
    intraspecies homolog to LBP,low
    Homologene
    FAMILY
  • BPI/LBP family
  • BPI/LBP/Plunc superfamily
  • CATEGORY transport carrier
    SUBCELLULAR LOCALIZATION extracellular
    basic FUNCTION
  • involved in the transfer of insoluble cholesteryl esters in the reverse transport of cholesterol
  • playing a key role in the determination of high-density lipoprotein (HDL) levels via its action on intravascular HDL metabolism
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism lipid/lipoprotein
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) CETPD
    Susceptibility
  • to coronary heart disease and carotid atherosclerosis
  • to exceptional longevity (Barzilai 06)
  • HDL cholesterol level QTL10 (Spirin 07)
  • the development of retinopathy of prematurity (ROP)
  • to age-related macular degeneration
  • Variant & Polymorphism SNP , other
  • taq1 B2B2 protective against coronary heart disease (associated with higher levels of plasma HDL-C )
  • functional interaction between -629C/A, -971G/A and -1337C/T polymorphisms is a major determinant of promoter activity and plasma CETP concentration(and HDL levels)
  • association between SNPs and the development of ROP
  • association of variants with age-related macular degeneration (Chen 2010)
  • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
    not contributing to the generation of prebeta-HDL in transgenic mice