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FLASH GENE
Symbol GNMT contributors: SGE/npt - updated : 13-08-2009
HGNC name glycine N-methyltransferase
HGNC id 4415
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
mono polymer homomer , tetramer
HOMOLOGY
interspecies homolog to murine Gnmt (92.2pc)
homolog to rattus Gnmt (92.8pc)
Homologene
FAMILY
CATEGORY enzyme , tumor suppressor
SUBCELLULAR LOCALIZATION     intracellular
intracellular,cytoplasm,cytosolic
basic FUNCTION
  • regulating the ratio of S adenosylmethionine to S adenosylhomocysteine and sarcosine
  • detoxification pathway in liver cells
  • favorable prognosis predictor for cholangiocarcinoma (Huang 2008)
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism aminoacid
    signaling
    methionine
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) GNMT
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    in hepatocellular carcinoma
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS