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FLASH GENE
Symbol GNMT contributors: SGE/npt - updated : 13-08-2009
HGNC name glycine N-methyltransferase
HGNC id 4415
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveliver   highly
 liverportal space   
Endocrinepancreas    
Reproductivemale systemprostate   
Urinarykidneynephron   
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period fetal
Text liver (periportal region)
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
mono polymer homomer , tetramer
HOMOLOGY
interspecies homolog to murine Gnmt (92.2pc)
homolog to rattus Gnmt (92.8pc)
Homologene
FAMILY
CATEGORY enzyme , tumor suppressor
SUBCELLULAR LOCALIZATION     intracellular
intracellular,cytoplasm,cytosolic
basic FUNCTION
  • regulating the ratio of S adenosylmethionine to S adenosylhomocysteine and sarcosine
  • detoxification pathway in liver cells
  • favorable prognosis predictor for cholangiocarcinoma (Huang 2008)
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism aminoacid
    signaling
    methionine
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) GNMT
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    in hepatocellular carcinoma
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS