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FLASH GENE

Symbol

GNMT

contributors: SGE/npt - updated : 13-08-2009

HGNC name	glycine N-methyltransferase
HGNC id	4415

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_018960 6 - 1091 NP_061833 32.6 295 - -

EXPRESSION

Type

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive liver       highly   liver portal space       Endocrine pancreas         Reproductive male system prostate       Urinary kidney nephron

cell lineage

cell lines

fluid/secretion

at STAGE

physiological period

fetal

Text	liver (periportal region)

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

mono polymer

homomer , tetramer

HOMOLOGY

interspecies	homolog to murine Gnmt (92.2pc)
	homolog to rattus Gnmt (92.8pc)

Homologene

FAMILY

CATEGORY

enzyme , tumor suppressor

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,cytosolic

basic FUNCTION	regulating the ratio of S adenosylmethionine to S adenosylhomocysteine and sarcosine
	detoxification pathway in liver cells
	favorable prognosis predictor for cholangiocarcinoma (Huang 2008)

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

aminoacid

signaling

methionine

a component

INTERACTION

DNA

RNA

small molecule

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

GNMT

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --low   in hepatocellular carcinoma

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS