Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol C3AR1 contributors: mct - updated : 08-09-2014
HGNC name complement component 3a receptor 1
HGNC id 1319
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • two extracellular loop
  • seven hydrophobic membrane spenning helices and large secund extracellular loop (172AA) between the fourth and the fifth transmembrane domain
  • ten potential phosphorylation sites within its C-terminus
    • HOMOLOGY
    interspecies homolog to murine C3AR1
    intraspecies homolog to C5A receptor
    Homologene
    FAMILY family 1 of G protein coupled receptor
    CATEGORY receptor
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • C3AR1 activation-induced depression of cAMP was associated with enhanced capacity of dendritic cells (DCs) for antigen uptake and T-cell stimulation
  • C3AR1 in macrophages, and potentially adipocytes, plays an important role in adipose tissue homeostasis and insulin resistance
  • its phosphorylation at multiple sites mediates desensitization, ARRB2 recruitment and inhibition of NFKB1 activity in mast cells
  • specific role for C3AR1 in constraining neutrophil mobilization in response to intestinal injury
  • C3AR1 and CD46 activation via intrinsic generation of their respective ligands is an integral part of human Th1 (but not Th2) immunity
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS inflammation
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • ADRBK1, ADRBK2 are involved in C3AR1 desensitization
  • GRK5 and GRK6 promote C3A-induced mast cell degranulation but inhibit ERK1/2 phosphorylation via C3AR1 desensitization-independent mechanisms
  • roles for SLC9A3R1 and SLC9A3R2 on the regulation of C3AR1 signaling in human mast cells
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --low  
    of C3aR mRNA and protein expression in placentas with preeclampsia compared to controls
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • C3aR(-/-) mice also mobilized more circulating neutrophils after granulocyte colony-stimulating factor infusion compared with WT mice