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FLASH GENE

Symbol

C3AR1

contributors: mct - updated : 08-09-2014

HGNC name	complement component 3a receptor 1
HGNC id	1319

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

EXPRESSION

Type

widely

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol blood / hematopoietic spleen         Cardiovascular heart         Digestive intestine small intestine       Reproductive female system ovary       Respiratory lung         Urinary kidney tubule convoluted tubule   highly Homo sapiens

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Connective adipose white   highly Homo sapiens Nervous central

cells

System Cell Pubmed Species Stage Rna symbol Urinary epithelial cell Homo sapiens

cell lineage	differentiated hematopoietic cell lineage
cell lines
fluid/secretion

at STAGE

physiological period

pregnancy

Text

placenta

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	two extracellular loop
	seven hydrophobic membrane spenning helices and large secund extracellular loop (172AA) between the fourth and the fifth transmembrane domain
	ten potential phosphorylation sites within its C-terminus

HOMOLOGY

interspecies

homolog to murine C3AR1

intraspecies

homolog to C5A receptor

Homologene

FAMILY

family 1 of G protein coupled receptor

CATEGORY

receptor

SUBCELLULAR LOCALIZATION

plasma membrane

basic FUNCTION	C3AR1 activation-induced depression of cAMP was associated with enhanced capacity of dendritic cells (DCs) for antigen uptake and T-cell stimulation
	C3AR1 in macrophages, and potentially adipocytes, plays an important role in adipose tissue homeostasis and insulin resistance
	its phosphorylation at multiple sites mediates desensitization, ARRB2 recruitment and inhibition of NFKB1 activity in mast cells
	specific role for C3AR1 in constraining neutrophil mobilization in response to intestinal injury
	C3AR1 and CD46 activation via intrinsic generation of their respective ligands is an integral part of human Th1 (but not Th2) immunity

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

inflammation

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein	ADRBK1, ADRBK2 are involved in C3AR1 desensitization
	GRK5 and GRK6 promote C3A-induced mast cell degranulation but inhibit ERK1/2 phosphorylation via C3AR1 desensitization-independent mechanisms
	roles for SLC9A3R1 and SLC9A3R2 on the regulation of C3AR1 signaling in human mast cells

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional     --low   of C3aR mRNA and protein expression in placentas with preeclampsia compared to controls

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS

C3aR(-/-) mice also mobilized more circulating neutrophils after granulocyte colony-stimulating factor infusion compared with WT mice