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FLASH GENE
Symbol C3AR1 contributors: mct - updated : 08-09-2014
HGNC name complement component 3a receptor 1
HGNC id 1319
Location 12p13.31      Physical location : 8.210.918 - 8.218.955
Synonym name
  • C3a anaphylatoxin chemotactic receptor
    • Synonym symbol(s) AZ3B, C3AR, HNFAG09, EVI146
    DNA
    TYPE functioning gene
    STRUCTURE 8.04 kb     2 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked   status provisional
    Map pter - D12S99 - SLC9A1 - GAPDH - DRPLA - PTMS - GNB3 - PEX5 - POLR2C - D12S358 - D12S77 - C3AR1 - CD69 - cen
    Authors GeneMap98
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    2 - 1985 - 482 - 1998 9710219
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    blood / hematopoieticspleen    
    Cardiovascularheart    
    Digestiveintestinesmall intestine   
    Reproductivefemale systemovary   
    Respiratorylung    
    Urinarykidneytubuleconvoluted tubule highly Homo sapiens
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectiveadiposewhite highly Homo sapiens
    Nervouscentral   
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Urinaryepithelial cell Homo sapiens
    cell lineage differentiated hematopoietic cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period pregnancy
    Text placenta
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • two extracellular loop
  • seven hydrophobic membrane spenning helices and large secund extracellular loop (172AA) between the fourth and the fifth transmembrane domain
  • ten potential phosphorylation sites within its C-terminus
    • HOMOLOGY
    interspecies homolog to murine C3AR1
    intraspecies homolog to C5A receptor
    Homologene
    FAMILY family 1 of G protein coupled receptor
    CATEGORY receptor
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • C3AR1 activation-induced depression of cAMP was associated with enhanced capacity of dendritic cells (DCs) for antigen uptake and T-cell stimulation
  • C3AR1 in macrophages, and potentially adipocytes, plays an important role in adipose tissue homeostasis and insulin resistance
  • its phosphorylation at multiple sites mediates desensitization, ARRB2 recruitment and inhibition of NFKB1 activity in mast cells
  • specific role for C3AR1 in constraining neutrophil mobilization in response to intestinal injury
  • C3AR1 and CD46 activation via intrinsic generation of their respective ligands is an integral part of human Th1 (but not Th2) immunity
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS inflammation
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • ADRBK1, ADRBK2 are involved in C3AR1 desensitization
  • GRK5 and GRK6 promote C3A-induced mast cell degranulation but inhibit ERK1/2 phosphorylation via C3AR1 desensitization-independent mechanisms
  • roles for SLC9A3R1 and SLC9A3R2 on the regulation of C3AR1 signaling in human mast cells
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --low  
    of C3aR mRNA and protein expression in placentas with preeclampsia compared to controls
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • C3aR(-/-) mice also mobilized more circulating neutrophils after granulocyte colony-stimulating factor infusion compared with WT mice