Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol FNTB contributors: mct - updated : 22-06-2018
HGNC name farnesyltransferase, CAAX box, beta
HGNC id 3785
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
five PFTB repeats
HOMOLOGY
Homologene
FAMILY protein prenyltransferase beta subunit family
CATEGORY enzyme
SUBCELLULAR LOCALIZATION     plasma membrane
    intracellular
intracellular,cytoplasm,cytosolic
intracellular,cytoplasm,cytoskeleton,microtubule
basic FUNCTION
  • promoting the prenylation of Ras, first step of a series of post translational modification of RAS
  • required for its association with the inner surface of the plasma membrane
  • also involved in maturation of other proteins including Ras family members, the gamma subunit of G proteins and nuclear lamins
  • enzyme responsible for posttranslational modification of proteins carrying a carboxy-terminal CaaX motif (
  • with HDAC6 are present in a protein complex together with microtubules
  • via its tubulin-association, is a critical upstream regulator of HDAC6 activity and its expression could help stratify cancer patients that would most benefit from this treatment
  • FNTB and PGGT1B are required for the homeostasis of skin keratinocytes
  • is not dispensable and PPGT1B is crucial for the vitality of hepatocytes
  • catalyzes the biologically relevant lipidation of up to several hundred cellular proteins (PMUD: 22992747)
  • FNTB signaling plays a significant role in acute pancreatitis (AP) by regulating neutrophil infiltration and tissue injury via the neutrophil expression of macrophage-1 antigen
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • farnesyltransferase is an heterodimer of an alpha and a beta subunit (FNTA, FNTB)
    • INTERACTION
    DNA
    RNA
    small molecule metal binding,
    binds 1 zinc ion per subunit
    protein
    cell & other
  • binds microtubules directly via its alpha subunit, and this association requires the C terminus of tubulin
    • REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    digestive  
    might constitute a target in the management of severe acute pancreatitis (AP)
    ANIMAL & CELL MODELS
  • hepatocyte-specific Fntb knockout mice survived but exhibited hepatocellular disease and elevated transaminases