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FLASH GENE

Symbol

FNTB

contributors: mct - updated : 22-06-2018

HGNC name	farnesyltransferase, CAAX box, beta
HGNC id	3785

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
STRUCTURE	75.86 kb     11 Exon(s)

10 Kb 5' upstream gene genomic sequence study

text structure

a CAAX box in the promoter

MAPPING

cloned

Y

linked

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_001202559 11 - 2894 - 498 - 2011 21268067

EXPRESSION

Type

widely

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive mouth tongue     highly Nervous brain       highly Reproductive female system uterus cervix   highly Respiratory respiratory tract trachea     highly Urinary kidney       highly

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

five PFTB repeats

HOMOLOGY

Homologene

FAMILY

protein prenyltransferase beta subunit family

CATEGORY

enzyme

SUBCELLULAR LOCALIZATION	plasma membrane
	intracellular
	intracellular,cytoplasm,cytosolic
	intracellular,cytoplasm,cytoskeleton,microtubule

basic FUNCTION	promoting the prenylation of Ras, first step of a series of post translational modification of RAS
	required for its association with the inner surface of the plasma membrane
	also involved in maturation of other proteins including Ras family members, the gamma subunit of G proteins and nuclear lamins
	enzyme responsible for posttranslational modification of proteins carrying a carboxy-terminal CaaX motif (
	with HDAC6 are present in a protein complex together with microtubules
	via its tubulin-association, is a critical upstream regulator of HDAC6 activity and its expression could help stratify cancer patients that would most benefit from this treatment
	FNTB and PGGT1B are required for the homeostasis of skin keratinocytes
	is not dispensable and PPGT1B is crucial for the vitality of hepatocytes
	catalyzes the biologically relevant lipidation of up to several hundred cellular proteins (PMUD: 22992747)
	FNTB signaling plays a significant role in acute pancreatitis (AP) by regulating neutrophil infiltration and tissue injury via the neutrophil expression of macrophage-1 antigen

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

farnesyltransferase is an heterodimer of an alpha and a beta subunit (FNTA, FNTB)

INTERACTION

DNA

RNA

small molecule	metal binding,
	binds 1 zinc ion per subunit

protein

cell & other

binds microtubules directly via its alpha subunit, and this association requires the C terminus of tubulin

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Susceptibility

Variant & Polymorphism

Candidate gene
Marker
Therapy target
	System Type Disorder Pubmed digestive     might constitute a target in the management of severe acute pancreatitis (AP)

ANIMAL & CELL MODELS

hepatocyte-specific Fntb knockout mice survived but exhibited hepatocellular disease and elevated transaminases