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FLASH GENE

Symbol

SOX8

contributors: mct - updated : 02-10-2019

HGNC name	SRY (sex determining region Y)-box 8
HGNC id	11203

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

ATR16

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --over   in triple-negative breast cancer (TNBC) tumoral     --over   high expression of SOX8 usually has a poor independent prognostic factor for Colorectal cancer

Susceptibility

Variant & Polymorphism

Candidate gene	for mental retardation in ATR16 patients with 16p microdeletion
Marker	early glial marker that may provide more detailed insight into the cellular makeup and consequent behaviour of medulloblastomas
Therapy target
	System Type Disorder Pubmed cancer reproductive breast ZEB1-SOX8 regulatory axis could be a promising therapeutic target for triple-negative breast cancer (TNBC)

ANIMAL & CELL MODELS

phenotypes in adult Sox8-deficient mice include mild osteopenia, late-onset male infertility, and reduced weight