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FLASH GENE
Symbol ZNRD1 contributors: mct/npt - updated : 22-02-2010
HGNC name zinc ribbon domain containing 1
HGNC id 13182
Location 6p21.3      Physical location : 1.269.272 - 30.032.685
Synonym name
  • transcription-associated zinc ribbon protein
  • RNA polymerase I small specific subunit Rpa12
    • Synonym symbol(s) hZR14, HTEX-6, tctex-6, RPA12, MGC13376, TEX6
    DNA
    TYPE functioning gene
    STRUCTURE 3.65 kb     5 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    text Variants a and b encode the same protein
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    5 - 751 14 126 - Fan (2000)
    4 - 859 14 126 - Fan (2000)
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • two zinc ribbon domains at the N and C termini
    • HOMOLOGY
    Homologene
    FAMILY
  • archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family
    • CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,nucleolus
    basic FUNCTION
  • transcription-associated gene, that significantly suppress the cell proliferation of stomach cancer cells (Hong 2005)
  • may play an important role in the regulation of gastric carcinogenesis (Hong 2005)
  • may play an important role in the control of human gastric cancer development by regulating cell proliferation (Hong 2004)
  • might play an important role in the process of DNA damage and repair by regulating the expression of ERCC1 (Guo 2008)
  • might play an important role in esophageal carcinogenesis (Zhao 2009)
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with PPP1R1B (Hong 2007)
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    in gastric cancer tissues as compared to the matched adjacent nonneoplastic tissues (Hong 2004)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
  • a potential therapeutic target in gastric cancer (Hong 2004)
  • new target in treatment of stomach cancer (Hong 2005)
    • ANIMAL & CELL MODELS