| protein
| BMPER (bone morphogenetic protein [BMP]-binding endothelial cell precursor-derived regulator) |
|
BMP8B, BMPR1A, BMPR1B, BMPR2 |
|
USAG-1 |
|
osteogenic protein (OP)-1 |
|
activin receptor-like kinase 3(ALK-3) and ALK-6 |
|
TWSG1 twisted gastrulation homolog 1 |
|
COL4A1 |
|
interacting with GREM1 (BMP4 and GREM1, which are highly expressed by fetal skeletal muscle side population and main population cells, respectively, are regulators of myogenic progenitor proliferation)  |
|
GREM2 might serve as a mediator to antagonize BMP4 signaling by WNT |
|
harmonious interactions between NOGGIN and BMP4 in periodontal ligament-forming cells, which show higher cell proliferation than neighboring cells, might be important for proper periodontium development |
|
specifically interacts with BMP15 protein (blocks the epidermal-inducing activity of BMP4 protein) |
|
WFIKKN1 and WFIKKN2 proteins are antagonists of MSTN and GDF11, but in the case of TGFB1, BMP2 and BMP4 they function as growth factor binding proteins |
|
BMP2 and BMP4 bind to neogenin (NEO1) |
|
BMP4 and SOX9 are potential candidate regulators of phenotypic change of mesangial cells in the advanced stage of diabetic nephropathy |
|
regulated JUND activity at the transcriptional regulation and post-translational modification levels |
|
was also able to increase ZFP423 gene activation, adding another layer of cross-talk in promoting adipogenic differentiation |
|
CHRDL1 protein antagonizes BMP4 activity and induces spinal cord& |
|
8209;derived NSCs to differentiate into neurons |
|
BMP4 antagonist NOG attenuates valve interstitial cells (VICs) activation and biomineralization |
|
BMP4 is a mediator of WWTR1-induced cell migration (WWTR1 induces BMP4 transcription through the TEAD family of transcription factors, which mediate BMP4 promoter activation through binding to TEAD response element 1) |
|
link between PTK2 and BMP4 induction of mesenchymal stem cells (MSCs) adipogenesis, and may indicate a potential therapeutic approach targeting PTK2 for dealing with obesity |
|
MSX1 is among several transcription factors that are induced by epithelial BMP4 and that, in turn, are necessary for the induction and maintenance of dental mesenchymal BMP4 expression |
|
BMP4 induces MITF expression in pluripotent stem cells and EDN3 subsequently promotes differentiation of these MITF expressing cells along the melanocyte lineage |
|
ROCK1 negatively regulates BMP4-stimulated BGLAP synthesis via the MAPK14 pathway in osteoblasts |
|
regulation of CHST11 expression by opposing effects of arylsulfatase B on BMP4 and WNT9A |
|
BMP4-dependent transcription is negatively autoregulated in part by SIN3B alternative splicing, and RBM39 plays a role in this process |
|
TBX3 represses BMP4 transcription and is required in the eye field for both neural induction and normal eye formation |
| Other morbid association(s)
|
| Type | Gene Modification | Chromosome rearrangement | Protein expression | Protein Function
|
|---|
| tumoral
|
|
| --over
|
| |
in patients with fibrodysplasia ossificans progressive (FOP) | | constitutional
|
|
| --over
|
| |
in a syndrome of axial skeletal malformations and heterotopic ossification of the neck and back (ASMHO), analog to the short ear mouse | | constitutional
| germinal mutation
|
|
|
| |
in ASD, VSD | | constitutional
|
|
| --over
|
| |
in synovial chondromatosis | | constitutional
|
|
| --over
|
| |
in RPE cells in both the early and late form of dry Age-related Macular Degeneration | | constitutional
|
|
|
| loss of function
| |
of SIX2 and BMP4, could affect kidney development at multiple stages, leading to the congenital anomalies observed in patients with renal hypodysplasia | | tumoral
| germinal mutation
|
|
|
| |
in colorectal cancer (CRC) | | constitutional
|
| deletion
|
|
| |
detected in a patient affected with SHORT syndrome | | constitutional
|
|
| --over
|
| |
may be associated with Sertoli cell-only syndrome and maturation arrest in spermatogonia or spermatocytes | | constitutional
|
|
| --over
|
| |
aberrant BMP4-mediated signaling in cranial neural crest (CNC) cells leads to mis-patterned facial skeleton and congenital bony syngnathia | |
