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FLASH GENE
Symbol DGCR6 contributors: npt - updated : 22-06-2005
HGNC name DiGeorge syndrome critical region gene 6
HGNC id 2846
PROTEIN
PHYSICAL PROPERTIES Hydrophobic
STRUCTURE
motifs/domains
  • hydrophobic N-terminal stretch of amino acids at position 49-69
    • conjugated PhosphoP
    HOMOLOGY
    interspecies homolog to murine Dgcr6
    intraspecies homolog to GDL and LAMC1
    Homologene
    FAMILY
  • gonadal family
    • CATEGORY adhesion
    SUBCELLULAR LOCALIZATION extracellular
        intracellular
    intracellular,nucleus
    text extracellular matrix
    basic FUNCTION
  • maybe playing a role in neural crest cell migration into the third and fourth pharyngeal pouches
    • CELLULAR PROCESS cell communication
    PHYSIOLOGICAL PROCESS development
    text histogenesis, organogenesis
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with LMP1 (transactivation)
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in B cell transformed by EBV
    constitutional        
    Di George syndrome
    Susceptibility to schizophrenia
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS