| protein
| POR1  |
|
Nef-associated kinase |
|
guanine nucleotide dissociation inhibitor, GDI |
|
T-lymphoma invasion and metastasis factor 1, Tiam1 |
|
with KRAS and RHoA, bind to RAP1GDS1 in both active and inactive forms which requires the presence of poly-basic residues in the C-termini of the GTPases |
|
TRE17 |
|
insulin receptor substrate (IRS) p53, IRSp53 |
|
CDC42, WAS to the cytoskeletal regulation of B lymphocytes |
|
interaction with FLNB, a scaffolding protein connecting also VAV2and KDR proteins for endothelial cell motility |
|
interaction between full-length MTSS1L and RAC1 is implicated in membrane deformation and subjected to a growth factor-mediated regulation through the C-terminal sequence |
|
(SUMO) E3-ligase, PIAS3 |
|
OBSCN is a specific activator of RHOQ but not the Rho GTPases RAC1 and CDC42 |
|
RAC1 and RAC3 interact with GIT1, a multifunctional Arf-GAP protein, which regulates cell-matrix adhesion, cell spreading and endocytosis |
|
CGNL1 is a regulator of the activity of two small GTPases, RAC1 and RHOA, through the functional interaction with their respective activators, TIAM1 and ARHGEF2 |
|
binding of RAC1 to MTOR does not depend on the GTP-bound state of RAC1, but on the integrity of its C-terminal domain |
|
interaction between LRRK2 and the Rho GTPase, RAC1, which plays a critical role in actin cytoskeleton remodeling necessary for the maintenance of neurite morphology |
|
SH3BP1 downregulates RAC1 at the motile-cell front, indicating that RAC1 inactivation in this location, as well as its activation by GEF proteins, is a fundamental requirement for cell motility |
|
EHD2 regulates trafficking from the plasma membrane by controlling RAC1 activity |
|
RHOC, and RAC1 are essential, for IGFBP1-induced extravillous trophoblast (EVT migration |
|
CRB3 and the RAC1-PI3K module are antagonists, and the fine balance between the activities of these proteins is crucial to maintain epithelial organization and an appropriate apical to basolateral ratio |
|
SSX2IP mediates the activation of RAC1 through VAV2 |
|
role of the HACE1 E3 ubiquitin-ligase in controlling RAC1 ubiquitylation and activity |
|
PARD3 regulates RAC1 activation by BDNF but not by NRG1-Type III in Schwann cells, although both ligands activate RAC1 |
|
OPHN1 exhibits strong GTPase-stimulating activity towards RHOA, CDC42, and RAC1 and regulates cell adhesion and spreading |
|
BECN1 bound to RAC1, recruited to early phagocytotic cups, and required for apoptotic cell internalization |
|
regulates cell migration and cell-cell adhesion through RAC1 ( |
|
interaction with NEDD4, that requires the hypervariable C-terminal domain of RAC1 and the WW domains of NEDD4 |
|
HDAC3-RAC1 interaction, but not HDAC3 activity, is necessary for down-regulation of HDAC2 by RAC1 |
|
upon clustering of ICAM1, the Rho-guanine nucleotide exchange factor TRIO activates RAC1, prior to activating RHOG, in a filamin-dependent manner |
|
RIN2 connects three GTPases, RRAS, RAB5A and RAC1, to promote endothelial cell adhesion through the regulation of integrin internalization and RAC1 activation |
|
TNFAIP8L2 binds to the C terminus of RAC1 suggesting that it may regulate membrane translocation of RAC1 |
|
NODAL signaling regulates endodermal cell motility and actin dynamics via RAC1 and PREX1 |
|
crucial role of S100A10 in actin dynamics promoting cell spreading via RAC1 activation |
|
CD81-RAC1 interaction was direct and independent of RAC1 activation status (interaction of RAC1 with the C-terminal cytoplasmic domain of CD81 is a novel regulatory mechanism of the GTPase activity turnover) |
|
PLXNB1 binds in a GTP-dependent manner to RAC1, RAC2, RAC3, RND1, RND2, RND3, and RHOD |
|
FHOD1 is activated by the small GTPase RAC1, RAC1 was enriched and activated at the membrane surrounding actin tails |
|
GRIN3A binds GIT1, a postsynaptic scaffold that assembles actin regulatory complexes, including the RAC1 guanine nucleotide exchange factor ARHGEF7, to promote RAC1 activation in spines |
|
RACGAP1 negatively controls the activity of RAC1 and CDC42, which are key molecular switches acting on the microtubule and actin cytoskeleton and controlling various cell processes such as proliferation, adhesion and motility |
|
CHRM3 facilitates interaction of the CDH5-based adherens junctional complex and the actin-based cytoskeleton by maintaining RAC1 activity, which regulates the interaction between IQGAP1/RAC1 and IQGAP1/CTNNB1, and may contribute to endothelial barrier function under physiological conditions |
|
NCK1-ELMO1 interaction promoting RAC1 activation and cell motility |
|
serine/threonine protein kinase AKT2 is critically involved in insulin-dependent RAC1 activation |
|
NAV1 interacts and colocalizes with TRIO, a Rho guanine nucleotide exchange factor that enables neurite outgrowth by activating the Rho GTPases RAC1 and RHOG |
|
PLEKHG4 regulates RAC1 downstream of AKT2, leading to the stimulation of glucose uptake in skeletal muscle |
|
DDX3X modulates cell adhesion and motility and cancer cell metastasis via RAC1-mediated signaling pathway |
|
RCC2, attenuates RAC1 activation outside the protrusive tip by binding to the RAC1 switch regions and competitively inhibiting GEF action, thus preventing off-axial protrusion |
|
ARHGEF7 and GIT1 are required for synaptic GABA(A)R surface stability through the activity of the GTPase RAC1 and downstream effector PAK1 |
|
TRIO is a mitotic GEF of RAC1, and TRIO controls RAC1 activation and subsequent F-actin remodeling in dividing cells |
|
PICK1 binds RAC1 and CDC42, via distinct but overlapping binding sites |
|
to activate RAC1 and consequently PYGM, PRKCQ phosphorylates ARHGEF6 in T cells |
|
importance of spatio-temporal regulation of the actin cytoskeleton through TRIO and RAC1 at CDH5-based cell-cell junctions in the maintenance of the endothelial barrier |
|
CSNK2A1 interacts at the neuromuscular synapse with RPSN, RAC1, YWHAG, and DOK7 proteins and phosphorylates the latter two |
|
role for RALA downstream of RAC1 in skeletal muscle insulin signalling |
|
SESTD1 may likely act as a negative regulator of the RAC1-TRIO signaling pathway to reduce dendritic spine density and lower excitatory synaptic transmission in hippocampal neurons |
|
RAC1 initiates its own inactivation by decreasing PREX2 GEF activity |
|
MARCKS upregulation increases VSMC motility by activation of RAC1 and CDC42 |
|
assembles with multiple members of the WASL complex and the RhoGTPase RAC1 and modulates their activity |
|
RAB23 promotes squamous cell carcinoma cells migration and invasion by regulating ITGB1/TIAM1/RAC1 pathway |
|
PREX1 is a guanine-nucleotide exchange factor (GEF) that activates the small G protein (GTPase) RAC1 to control RAC1-dependent cytoskeletal dynamics, and thus cell morphology |
|
RAB23 serves as an important oncoprotein in human astrocytoma by regulating cell invasion and migration through RAC1 activity |
|
HACE1 controls cell proliferation and ubiquitylates the small GTPase RAC1 to target it to proteasomal degradation |
|
SH3BP1 specifically inactivating RAC1 and its target WASF2 is required for cell motility, thus regarded as an essential regulator of cancer cell metastasis |
|
causal relationship between increased RAC1/CFL1 signaling, synaptic defects, and impaired sensory processing in FRAXA and role for impaired RAC1/CFL1 signaling in the aberrant spine morphology and spine density associated with FRAXA |
|
UBE2I acts as a functional binding partner of FYB1 and plays a selective role in integrin-mediated T cell adhesion via modulation of RAP1A-RASSF5 membrane recruitment and RAC1 activation |
|
ARHGAP11A directly interacted with RAC1B independent of RHO GTPase- activating activity |
|
TRIO acts as a key regulator of neuronal migration, axonal outgrowth, axon guidance, and synaptogenesis by activating the GTPase RAC1 and modulating actin cytoskeleton remodeling |
