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FLASH GENE
Symbol BAZ1B contributors: mct/npt - updated : 24-10-2018
HGNC name bromodomain adjacent to zinc finger domain, 1B
HGNC id 961
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a N terminal WAC domain,followed by
  • a receptor interacting domain (LXXLL)
  • a BAZ1 and a BAZ2 domains
  • a WAKZ motif adjacent to a (C4HC3) PHD zinc finger motif
  • a stretch of 13 GLU and a C terminal bromodomain, conserved zinc-binding core with two variable loops
    • HOMOLOGY
    interspecies homolog to murine Baz1b
    Homologene
    FAMILY
  • bromodomain family
  • WAL family
    • CATEGORY regulatory , transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,chromatin/chromosome
    basic FUNCTION
  • involved in chromatin-dependent regulation of transcription
  • being shared and a functionally indispensable subunit of the WICH complex for DNA repair and the WINAC complex for transcriptional control (Yoshimura 2009)
  • phosphorylating Tyr142 of H2AFX and regulating its DNA damage response (Xiao, 2009)
  • involved in vitamin D-mediated transcription and replication as a component of two distinct ATP-dependent chromatin remodeling complexes, WINAC and WICH, respectively (Cavellan 2006)
    • CELLULAR PROCESS nucleotide, chromatin organization, remodeling
    nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • of chromatin remodeling complexes CHRAC (chromatin accessibility complex), WCRF
  • complexing with SMARCA5 (BAZ1B/SMARCA5 complex has a role in the maintenance of chromatin structures during DNA replication), and BAZ1B-SMARCA5 assembly is involved in RNA polymerase III transcription (Cavellan 2006)
  • part of a multiprotein complex that contains WICH, a chromatin remodelling complex containing BAZ1B (Williams syndrome transcription factor), SMARCA5, MYO1C (Percipalle 2006)
  • subunit of WINAC, which is a subclass of the SWI/SNF-type ATP-dependent chromatin remodeling complexes (Yoshimura 2009)
  • component of WINAC, that is indispensable for gene regulation by VDR through its chromatin remodeling activity (Oya 2009)
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacts with PCNA to target chromatin remodelling by SMARCA5 to replication foci
  • BAZ1A and BAZ1B each recruit SMARCA5 to sites of damaged chromatin and promote survival
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional   deletion    
    included in the Williams-Beuren commonly deleted region
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS