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FLASH GENE
Symbol BAZ1B contributors: mct/npt - updated : 24-10-2018
HGNC name bromodomain adjacent to zinc finger domain, 1B
HGNC id 961
EXPRESSION
Type ubiquitous
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveintestinelarge intestinecolon highly
 stomach   highly
Lymphoid/Immunelymph node   highly
 tonsils   highly
Reproductivefemale systemovary  highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a N terminal WAC domain,followed by
  • a receptor interacting domain (LXXLL)
  • a BAZ1 and a BAZ2 domains
  • a WAKZ motif adjacent to a (C4HC3) PHD zinc finger motif
  • a stretch of 13 GLU and a C terminal bromodomain, conserved zinc-binding core with two variable loops
    • HOMOLOGY
    interspecies homolog to murine Baz1b
    Homologene
    FAMILY
  • bromodomain family
  • WAL family
    • CATEGORY regulatory , transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,chromatin/chromosome
    basic FUNCTION
  • involved in chromatin-dependent regulation of transcription
  • being shared and a functionally indispensable subunit of the WICH complex for DNA repair and the WINAC complex for transcriptional control (Yoshimura 2009)
  • phosphorylating Tyr142 of H2AFX and regulating its DNA damage response (Xiao, 2009)
  • involved in vitamin D-mediated transcription and replication as a component of two distinct ATP-dependent chromatin remodeling complexes, WINAC and WICH, respectively (Cavellan 2006)
    • CELLULAR PROCESS nucleotide, chromatin organization, remodeling
    nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • of chromatin remodeling complexes CHRAC (chromatin accessibility complex), WCRF
  • complexing with SMARCA5 (BAZ1B/SMARCA5 complex has a role in the maintenance of chromatin structures during DNA replication), and BAZ1B-SMARCA5 assembly is involved in RNA polymerase III transcription (Cavellan 2006)
  • part of a multiprotein complex that contains WICH, a chromatin remodelling complex containing BAZ1B (Williams syndrome transcription factor), SMARCA5, MYO1C (Percipalle 2006)
  • subunit of WINAC, which is a subclass of the SWI/SNF-type ATP-dependent chromatin remodeling complexes (Yoshimura 2009)
  • component of WINAC, that is indispensable for gene regulation by VDR through its chromatin remodeling activity (Oya 2009)
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacts with PCNA to target chromatin remodelling by SMARCA5 to replication foci
  • BAZ1A and BAZ1B each recruit SMARCA5 to sites of damaged chromatin and promote survival
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional   deletion    
    included in the Williams-Beuren commonly deleted region
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS