Selected-GenAtlas references	SOURCE	GeneCards	NCBI Gene	Swiss-Prot	Ensembl
	HGNC	UniGene	Nucleotide	OMIM	UCSC

Home Page

FLASH GENE

Symbol

SLC6A4

contributors: mct - updated : 18-05-2016

HGNC name	solute carrier family 6 (neurotransmitter transporter, serotonin), member 4
HGNC id	11050

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

Susceptibility

to sudden infant death a possible association to bipolar affective disorder and personality traits in a primarily female population sample susceptibility gene for high cholesterol and heart disease susceptibility to major depression, to attention deficit hyperactivity disorder, to autism and rigid-compulsive behaviors to obsessive-compulsive disorder(OCD)

Variant & Polymorphism other	some evidence of allelic variation modulating anxiety-related traits
	promoter polymorphism increasing the risk of sudden infant death (L/L)
	L(A) allele was twofold overtransmitted to the patients with OCD
	a 44-bp insertion/deletion polymorphism in the upstream regulatory region (5-HTTLPR) and a VNTR polymorphism in the second intron (Stin2) increasing the risk of SIDS

Candidate gene
Marker
Therapy target
	System Type Disorder Pubmed psychiatry autism   major therapeutic target in autism psychiatry bipolar disorder   common targets of drugs extensively used for the treatment of multiple different pathologies, ranging from anorexia, depression, anxiety and other psychiatric as well as neurological disorders to gastrointestinal and uro-genital dysfunctions

ANIMAL & CELL MODELS

Sert(-/-) rats show decreased brain-derived neurotrophic factor (Bdnf) expression, as well as reduced levels of transcription factor regulating the neurotrophin transcription