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FLASH GENE
Symbol SLC6A2 contributors: mct - updated : 14-09-2011
HGNC name solute carrier family 6 (neurotransmitter transporter, noradrenalin), member 2
HGNC id 11048
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • twelve transmembrane segments (12TM)
  • N- and C-terminal ends facing the cytoplasmic side
    • HOMOLOGY
    Homologene
    FAMILY
  • sodium neurotransmitter symporter (SNF) family
  • Na+- and Cl--dependent neurotransmitter transporter family SLC6
    • CATEGORY transport carrier
    SUBCELLULAR LOCALIZATION     plasma membrane
    text
  • expressed on the plasma membranes of noradrenergic neurons
  • is also localized in raft-rich membrane domains, and this localization is dynamically regulated by kinases
    • basic FUNCTION
  • Na+ (and Cl-) dependent plasma membrane transporter
  • terminating the action of noradrenaline by its high affinity sodium-dependent reuptake into presynaptic terminals
  • mediating reuptake of norepinephrine released from neurons, and, as such, important regulator of noradrenergic neurotransmission
  • regulates both neurotransmission and homeostasis of norepinephrine in the nervous system
  • MAOA, SLC6A2, SLC6A3 may play important roles in regulating maternal monoamine neurotransmitters transferred across the placenta to the fetus
  • important in terminating neurotransmission
  • SLC6A3, SLC6A2, SLC6A4 facilitate the homeostatic balance of neurotransmitters in the synaptic cleft and thus, play a fundamental role in regulating neuronal activity
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component TACR1 forms physical complexes with SLC6A2
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • PRKCABP
  • MAOA in anorexia nervosa
  • interacting with SMARCA2 and MECP2 (increased SLC6A2 gene expression in response to membrane depolarization was strongly correlated with the dissociation of MECP2 and SMARCA2 complex on the unmethylated gene)
  • TACR1 mediates down-regulation of SLC6A2 via protein kinase C (PKC)
    • cell & other
  • target of psychotropic substances, such as tricyclic antidepressants and the drug of abuse, cocaine
    • REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
  • to orthostatic intolerance
  • anorexia nervosa
  • to attention-deficit hyperactivity disorder (ADHD)
    • Variant & Polymorphism other
  • A457P associated with orthostatic intolerance
  • -3081(A/T) polymorphism associated to attention-deficit hyperactivity disorder (ADHD)
    • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • loss of SLc6a2 function during embryonic development in the mouse deregulates signaling pathways that are critically involved in neural crest formation and noradrenergic cell differentiation