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FLASH GENE

Symbol

IL13RA1

contributors: mct - updated : 29-11-2014

HGNC name	interleukin 13 receptor, alpha 1
HGNC id	5974

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional     --over   at the transcriptional level in cisplastin-resistant cells constitutional     --over   on the suprabasal keratinocytes in the skin of atopic dermatitis and striking increase of staining was observed on all layers of keratinocyte in the skin of psoriasis

Susceptibility

Variant & Polymorphism SNP	including a variant associated primarily with high IgE level

Candidate gene
Marker	loss of IL13RA1 on islet-reactive T cells may be a biomarker for fading regional immune regulation and progression to overt diabetes
Therapy target

ANIMAL & CELL MODELS