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FLASH GENE
Symbol IL13RA1 contributors: mct - updated : 29-11-2014
HGNC name interleukin 13 receptor, alpha 1
HGNC id 5974
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • putative signal sequence
  • transmembrane domain
  • a N terminal FBN-type III like domain
  • two typical cytokine receptor like modules with the consensus WSEWS motif
  • a short cytoplasmic tail
    • HOMOLOGY
    interspecies homolog to murine Il13ra
    Homologene
    FAMILY
  • type I cytokine receptor family
  • type 5 subfamily
    • CATEGORY signaling cytokine , receptor
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • might be involved in the control of immunoglobulin E production
  • essential for allergen-induced airway hyperreactivity and mucus hypersecretion but not for fibroblast or alternative macrophage activation
  • can potentially regulates IL4-induced responses in the lung
  • essential for baseline IgE production, but Th2 and IgE responses to T cell-dependent antigens are IL13RA1-independent
  • central role for the IL13/IL13RA1 pathway in the regulation of intestinal epithelial cell Cl(-) secretion via up-regulation of CFTR, suggesting an important role for this pathway in secretory diarrhea
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • activating STAT6, jointly with IL4
  • ITGAM regulates IL13 activity in macrophages by directly interacting with IL13RA1
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    at the transcriptional level in cisplastin-resistant cells
    constitutional     --over  
    on the suprabasal keratinocytes in the skin of atopic dermatitis and striking increase of staining was observed on all layers of keratinocyte in the skin of psoriasis
    Susceptibility
    Variant & Polymorphism SNP including a variant associated primarily with high IgE level
    Candidate gene
    Marker
  • loss of IL13RA1 on islet-reactive T cells may be a biomarker for fading regional immune regulation and progression to overt diabetes
    • Therapy target
    ANIMAL & CELL MODELS