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FLASH GENE

Symbol

DLST

contributors: mct - updated : 07-05-2019

HGNC name	dihydrolipoamide S-succinyltransferase (E2 component of 2-oxo-glutarate complex)
HGNC id	2911

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

related resource

MITOP database

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral germinal mutation       in Pheochromocytomas and paragangliomas (PPGL)

Susceptibility

to Alzheimer disease to PPGL (Pheochromocytomas and paragangliomas)

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS

	neurotoxic effects of mitochondrial toxins were exacerbated in Dlst(+/-) mice
	overexpression of Dlst in wild-type mice protected against cardiac hypertrophy and dysfunction