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FLASH GENE
Symbol VPREB3 contributors: npt/ - updated : 14-03-2005
HGNC name pre-B lymphocyte gene 3
HGNC id 12710
Location 22q11.23      Physical location : 24.094.933 - 24.096.630
Synonym name
  • immunoglobulin pre B lymphocyte gene 3
  • VpreB3 protein
  • Synonym symbol(s) 8HS20, N27C7-2
    DNA
    TYPE functioning gene
    STRUCTURE 1.66 kb     2 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Map see IGLL@
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    2 - 602 13.58 123 - -
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    blood / hematopoieticspleen    
    Lymphoid/Immunelymph node    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / Hematopoieticbone marrow   
    Lymphoid    
    cell lineage cell lines representative of all stages of B-cell differentiation with the exception of plasmacytomas
    cell lines
    fluid/secretion
    at STAGE
    physiological period fetal, pregnancy
    Text liver, spleen, lymph node
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a N terminal signal peptide
  • three framework regions (FR) and three complementary regions in the order FR1 - CDR1 - FR2 - CDR2 - FR3 - CD3
  • HOMOLOGY
    interspecies homolog to murine 8hs20
    Homologene
    FAMILY
  • immunoglobulin superfamily
  • CATEGORY immunity/defense
    SUBCELLULAR LOCALIZATION
    basic FUNCTION
  • maybe contributing to mu chain transport in pre-B cells
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS