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FLASH GENE
Symbol RPS6KA5 contributors: mct/pgu - updated : 05-11-2020
HGNC name ribosomal protein S6 kinase, 90kDa, polypeptide 5
HGNC id 10434
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart    
Hearing/Equilibriumearinnercochlea highly
Nervousbrain   predominantly
Reproductivefemale systemplacenta  highly
Respiratoryrespiratory tractlarynx  highly
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period pregnancy
Text placenta
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • two non identical conserved kinase catalytic domains
  • an APE motif
  • a dual kinase domain
    • HOMOLOGY
    Homologene
    FAMILY ser/thr protein kinase family, S6 kinase subfamily
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus,nucleoplasm
    text
  • nucleus, predominantly
  • cytoplasm, partially
    • basic FUNCTION
  • ribosomal protein S6 kinase, serine/threonine kinase, non receptor type
  • may be mediating the growth factor and stress-induced activation of CREB
  • playing an essential role in the control of RELA transcriptional activity in response to TNF
  • acting downstream of the ERK1/2 (extracellular-signal-regulated kinase 1/2) and p38 MAPK (mitogen-activated protein kinase) signalling pathways in cells (Mccoy 2007) directly repressing transcription via phosphorylation of ser-1 of histone H2A
    • CELLULAR PROCESS protein, translation/synthesis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component complex with either ERK1 or ERK2 in quiescent cells which transiently dissociates following mitogenic stimulation
    INTERACTION
    DNA
    RNA
    small molecule
    ATP binding
    protein
  • RPS6 binding
  • phosphorylate the transcription factors CREB (cAMP-response-element-binding protein) and ATF1, and the chromatin proteins histone H3 and HMGN1 in response to either mitogenic stimulation or cellular stress
  • CSNK2B is a binding and regulatory partner for RPS6KA5
  • KMT2A/MLL1 is required for the genomic targeting of RPS6KA5, but not vice versa
  • role of RPS6KA5 in the induction of NFKB1 by the chemokine CX3CL1 in microglial cells
    • cell & other
    REGULATION
    activated by the activation of the ERK1/2 or p38 MAPK cascades but does not appear to require additional signalling inputs
    Other regulation controlled by multiple phosphorylation sites
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS