Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol TMOD4 contributors: mct - updated : 21-10-2016
HGNC name tropomodulin 4 (muscle)
HGNC id 11874
Location 1q21.3      Physical location : 151.142.463 - 151.148.547
Synonym name
  • tropomodulin 4
  • actin-capping protein
  • skeletal muscle tropomodulin
  • Synonym symbol(s) SK-TMOD, DKFZp779I0852
    DNA
    TYPE functioning gene
    STRUCTURE 6.09 kb     10 Exon(s)
    Genomic sequence alignment details
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    text alternative spliced
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    10 splicing 1322 39.2 345 - 2001 11716785
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart    
    Nervousbrain    
    Reproductivemale systemprostate   
    Visualeyelens   
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / Hematopoieticbone marrow   
    Connectiveadipose  highly Homo sapiens
    Muscularstriatumcardiac  
    Muscularstriatumskeletal highly Homo sapiens
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Blood/Hematopoieticerthrocyte
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • N terminal tropomyosin binding domain
  • a C terminal actin-binding domain
  • HOMOLOGY
    interspecies homolog to murine Tmod4
    Homologene
    FAMILY
  • tropomodulin family
  • CATEGORY motor/contractile
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytoskeleton
    basic FUNCTION
  • blocking the elongation and depolymerization of the actin filaments at the pointed end
  • TMOD3 and TMOD4 compensate for the absence of TMOD1 structurally but not functionally
  • TMOD1-TMOD3 but not TMOD4 nucleate actin filament assembly
  • is an actin-capping protein that binds to the two tropomyosins (TM) at the pointed end of the actin filament to prevent further actin polymerization and depolymerization
  • plays important role in thin filament length regulation and myofibril assembly
  • may play as a switch between myogenesis and adipogenesis, which resulted in the balanced development between skeletal muscle and adipose tissue
  • TMOD1, TMOD3, TMOD4 are novel regulators of actomyosin crossbridge formation and muscle contractility
  • appropriate levels of both TMOD4 and LMOD3 are required for embryonic myofibrillogenesis and, both proteins can function redundantly during skeletal muscle thin filament assembly
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • TMOD1 and TMOD4 cap thin filament pointed ends and functionally interact with the LMOD isoforms LMOD2 and LMOD3 to control myofibril organization, thin filament lengths, and actomyosin crossbridge formation in skeletal muscle fibers
  • cell & other
    REGULATION
    Other could be regulated directly by myogenic factors and adipogenic factors
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS