basic FUNCTION
| blocking the elongation and depolymerization of the actin filaments at the pointed end |
|
TMOD3 and TMOD4 compensate for the absence of TMOD1 structurally but not functionally |
|
TMOD1-TMOD3 but not TMOD4 nucleate actin filament assembly |
|
is an actin-capping protein that binds to the two tropomyosins (TM) at the pointed end of the actin filament to prevent further actin polymerization and depolymerization |
|
plays important role in thin filament length regulation and myofibril assembly |
|
may play as a switch between myogenesis and adipogenesis, which resulted in the balanced development between skeletal muscle and adipose tissue |
|
TMOD1, TMOD3, TMOD4 are novel regulators of actomyosin crossbridge formation and muscle contractility |
|
appropriate levels of both TMOD4 and LMOD3 are required for embryonic myofibrillogenesis and, both proteins can function redundantly during skeletal muscle thin filament assembly |