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FLASH GENE
Symbol TMOD3 contributors: mct - updated : 12-10-2016
HGNC name tropomodulin 3 (ubiquitous)
HGNC id 11873
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a N terminal tropomyosin binding domain and
  • a C terminal actin-binding domain, and C-terminal (LRR) domain having roles in the formation of neurite-like processes
    • HOMOLOGY
    interspecies homolog to murineTmod3
    Homologene
    FAMILY tropomodulin family
    CATEGORY motor/contractile
    SUBCELLULAR LOCALIZATION     plasma membrane,junction
        intracellular
    intracellular,cytoplasm,cytoskeleton
    text
  • localizes to lateral cell membranes in polarized epithelia of several cell types
  • TMOD1, TMOD2 and TMOD3 are associated with the cytoskeleton of non-muscle cells and their expression has distinct consequences on cell morphology
    • basic FUNCTION
  • blocking the elongation and depolymerization of the actin filaments at the pointed end
  • TMOD3-capped tropomyosin-actin filaments provide likely crucial links in the spectrin membrane skeleton of polarized epithelial cells, enabling the membrane skeleton to maintain cell shape
  • TMOD3 and TMOD4 compensate for the absence of TMOD1 structurally but not functionally
  • TMOD1-TMOD3 but not TMOD4 nucleate actin filament assembly
  • is an actin-capping protein that binds to the two tropomyosins (TM) at the pointed end of the actin filament to prevent further actin polymerization and depolymerization
  • is a protein that binds and caps the pointed ends of actin filaments in erythroid and nonerythoid cell types
  • novel function for TMOD3 in regulating actin remodeling or turnover in cells
  • regulation of actin polymerization by TMOD3 controls megakaryocyte actin organization and platelet biogenesis
  • TMOD1, TMOD2, TMOD3 regulates the length of actin filaments by capping the pointed ends in a tropomyosin (TM)-dependent manner
  • cap pointed ends of actin filaments and to be enriched in leading-edge ruffles and lamellipodia
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • TMOD3 binds actin monomers over an extended interface and nucleating activity depends on actin monomer binding and pointed end-capping activities, contributed by N- and C-terminal domains of TMOD3, respectivelyv
  • TMOD3 is a novel AKT2 effector regulating insulin-stimulated SLC2A4 exocytosis through cortical actin remodeling
  • two actin-related binding partners of PLS3, are CORO1C, and TMOD3
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --low  
    leads to impaired definitive erythropoiesis due to reduced progenitors, impaired erythroblastic island formation, and defective erythroblast cell-cycle progression and enucleation
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • serum anti-TPM3, anti-TMOD3, anti-STOML2 could be new markers for the early diagnosis of endometriosis
    • Therapy target
    ANIMAL & CELL MODELS