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FLASH GENE
Symbol SLCO2B1 contributors: shn - updated : 05-09-2010
HGNC name solute carrier organic anion transporter family, member 2B1
HGNC id 10962
Location 11q13.4      Physical location : 74.862.039 - 74.917.444
Synonym name
  • solute carrier family 21 (organic anion transporter), member 9
  • organic anion transporter B
  • organic anion transporter polypeptide-related protein 2
  • solute carrier family 21 member 9
  • solute carrier organic anion transporter family member 2B1
  • Synonym symbol(s) DKFZp686E0517, KIAA0880, OATP-B, OATP2B1, OATPB, SLC21A9, OATP-RP2, OATPRP2
    DNA
    TYPE functioning gene
    STRUCTURE 55.41 kb     14 Exon(s)
    MAPPING cloned Y linked N status confirmed
    Map cen - D11S4207 - D11S4119 - SLCO2B1 - D11S4128 - D11S4081 - qter
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    14 splicing 4354 85 709 choroid/RPE-complex and ciliary body St-Pierre et al, 2002; Kraft et al, 2010
    11 splicing 3922 - 565 - -
    14 splicing 4056 - 687 - -
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    blood / hematopoieticspleen   lowly
    Cardiovascularheart   lowly
    Digestiveliver   highly
    Endocrinepancreas   lowly
    Nervousbrain   lowly
    Reproductivefemale systemovary  lowly
     male systemtestis  lowly
    Respiratorylung   lowly
    Urinarykidney   lowly
    Visualeyeretina  lowly
     eyeanterior segmentiris lowly
     eyeanterior segmentcornea lowly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelialbarrier liningretinal pigment epithelium (RPE) highly
    Epithelialsecretoryglandularendocrine 
    Epithelialsecretoryglandularexocrine 
    Lymphoid    
    Muscularstriatumskeletal  
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Digestivehepatocyte
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • eight transmembrane domains
  • N-glycosylation sites
  • HOMOLOGY
    interspecies ortholog to Slco2b1, Rattus norvegicus
    ortholog to slco2b1, Danio rerio
    ortholog to SLCO2B1, Pan troglodytes
    ortholog to Slco2b1, Mus musculus
    Homologene
    FAMILY organic anion transporting polypeptide (OATP) family
    CATEGORY transport carrier
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • transport of 3(H) estrone-3-sulfate
  • a physiological role in the placental uptake of fetal-derived sulfated steroids (St-Pierre et al, 2002)
  • involved in de novo synthesis of placental estrogens but may contribute to the clearance of estrogen sulfates from foetal circulation (Ugele et al, 2008)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS active transport
    text organic anion transport
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS