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FLASH GENE
Symbol DUSP12 contributors: SGE/npt - updated : 05-04-2008
HGNC name dual specificity phosphatase 12
HGNC id 3067
Location 1q23.3      Physical location : 161.719.580 - 161.726.951
Synonym name
  • YVH1 protein-tyrosine phosphatase (S. cerevisiae) ortholog
  • vaccinia virus H1 (VH1)-like type
  • serine/threonine specific protein phosphatase
  • Synonym symbol(s) YVH1
    EC.number 3.1.3.16, 3.1.3.48
    DNA
    TYPE functioning gene
    STRUCTURE 7.37 kb     6 Exon(s)
    Genomic sequence alignment details
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Map cen - D1S635 - MNDA - DUSP12 - ATP1A2 - D1S2771 - D1S2705 - D1S2768 - D1S2844 - qter
    Authors Gene Map (98)
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    - - 1271 - 340 - -
    EXPRESSION
    Type widely
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    blood / hematopoieticspleen    
    Reproductivefemale systembreastmammary gland highly
     female systemuterus  highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Lymphoid    
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a phosphatase domain
  • a conserved C terminal non catalytic, cysteine-rich, zinc finger domain
  • HOMOLOGY
    interspecies ortholog to yeast S.cerevisiae YVH1 protein-tyrosine phosphatase,predominantly in the nucleus
    Homologene
    FAMILY
  • protein-tyrosine phosphatase family
  • non-receptor class dual specificity subfamily
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • may be involved in protein-protein interactions
  • negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which is associated with cellular proliferation and differentiation
  • cell survival phosphatase that co-operates with HSP70 to positively affect cell viability in response to cellular insults (Sharda 2009)
  • protects cells from oxidative stress (Bonham 2009)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binding to HSP70
  • cell & other
    REGULATION
    Other forming intramolecular disulfide bonds at the catalytic cleft to avoid irreversible inactivation during oxidative stress (Bonham 2009)
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility to type 2 diabetes (minor role)
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS