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FLASH GENE
Symbol RANBP3 contributors: mct/npt/pgu - updated : 31-05-2013
HGNC name RAN binding protein 3
HGNC id 9850
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Lymphoid/Immunethymus   highly
Reproductivemale systemtestis  highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Muscularstriatumskeletal highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • FXFG motifs characteristic of a subgroup of nucleoporins
  • a C terminal domain with similarity to RANBP1
    • HOMOLOGY
    Homologene
    FAMILY
    CATEGORY chaperone/stress , structural protein
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus
    basic FUNCTION
  • scaffold protein promoting the efficient assembly of the nuclear export complex
  • nuclear effector of the RAN pathway
  • is a direct export enhancer for beta-catenin, independent of its role as a XPO1-associated nuclear export cofactor
  • playing a role in mediating SMAD2/3 nuclear export and terminating TGF-beta signaling
  • acts as a XPO1 cofactor, enhancing NES export by stabilizing the export complex in the nucleus
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • nuclear export complex
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • linking exportin 1 (XPO1) to the regulator of chromosome condensation 1, CHC1 (RCC1)
  • RAN binding
  • preferentially bound to importin alpha 3 (KPNA4)
  • XPO1-mediated export is regulated by RANBP3, a Ran-interacting nuclear protein
  • PPM1A directly interacted with and dephosphorylated RANBP3 at Ser 58
    • cell & other
    REGULATION
    Other its phosphorylation links the Ras and PI3-kinase pathways to nucleocytoplasmic transport
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS